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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
UMR7364 CNRS UNISTRA, Strasbourg, Alsace, France.
Background: Aging is the main risk factor of cognitive neurodegenerative diseases such as Alzheimer's disease, with epigenome alterations as a contributing factor, however, it is not clear which biological mechanisms are common or disease-specific. Here we investigated epigenomic/genomic signatures in the hippocampus of mouse models of aging and of tauopathy, an AD-related feature.
Methods: Aging was modelled by comparing 18-month- versus 3-month-old WT mice.
Blood-derived APLP1 extracellular vesicles are potential biomarkers for the early diagnosis of brain diseases.
Sci Adv
January 2025
Department of Biotechnology, College of Life Science, CHA University, Gyeonggi-do 13488, Republic of Korea.
The early detection of neurodegenerative diseases necessitates the identification of specific brain-derived biomolecules in peripheral blood. In this context, our investigation delineates the role of amyloid precursor-like protein 1 (APLP1)-a protein predominantly localized in oligodendrocytes and neurons-as a previously unidentified biomarker in extracellular vesicles (EVs). Through rigorous analysis, APLP1 EVs from human sera were unequivocally determined to be of cerebral origin.
View Article and Find Full Text PDFImpact of gender on self-assessment accuracy among fourth-year French medical students on faculty's online Objective Structured Clinical Examinations.
BMC Med Educ
December 2024
Department of Infectious and Tropical Diseases, Hôpital Saint-Louis Et Lariboisière, AP-HP, Université Paris Cité, 1 Avenue Claude Vellefaux, Paris, F-75010, France.
Background: Historically, women have been shown to underestimate their abilities, while men often assess themselves more accurately or overestimate. This study aims to determine self-assessment accuracy during online Objective Structured Clinical Examinations (OSCEs) according to gender.
Methods: A prospective study was conducted among fourth-year medical students at Paris Cité University during faculty training OSCEs, utilizing Zoom® software for remote participation.
The clinical significance and burden of thyroid nodules discovered incidentally.
Ir J Med Sci
December 2024
School of Medicine, University College of Cork, Cork, Ireland.
Background: The majority of thyroid nodules are benign; however current guidelines suggest that thyroid incidentalomas should be appropriately evaluated to rule out malignancy.
Aims: This study aims to determine the incidence of thyroid incidentalomas and the likelihood that they harbour sinister pathology in the largest Irish cohort studied to-date.
Methods: A retrospective observational chart review was conducted using data from July 2018 to December 2018 using the Radiology Database in use at Cork University Hospital.
Accumulation of alpha-synuclein pathology in the liver exhibits post-translational modifications associated with Parkinson's disease.
iScience
December 2024
Department of Biomedical and Clinical Sciences, Department of Clinical Pathology, Linköping University, Linköping, Sweden.
Accumulating evidence demonstrates that alpha-synuclein (α-syn) pathology associated with Parkinson's disease (PD) is not limited to the brain, as it also appears in a select number of peripheral tissues including the liver. In this study, we identified a number of PD-associated α-syn post-translational modifications in the livers of (Thy-1)-h[A30P] mice, a mouse model of familial PD expressing human α-syn harboring the A30P mutation driven by a neuron-specific promoter. , we also demonstrate that human hepatocytes induce post-translational modifications following α-syn fibrillar (PFF) treatment.
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