AI Article Synopsis
- Nine soluble ligands, including interleukin-6 (IL-6) and interleukin-11 (IL-11), share the glycoprotein-130 (gp130) receptor, forming the IL-6 family of cytokines.
- Several members of this family, such as cardiotrophin-1 (CT-1) and leukemia inhibitory factor (LIF), may play key roles in cancer development.
- Understanding these cytokines and their pathways could lead to targeted therapies that either inhibit or enhance their activity, potentially improving cancer treatment outcomes.
Article Abstract
Nine soluble ligands [interleukin-6 (IL-6), interleukin-11 (IL-11), leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, interleukin-27 (IL-27), and interleukin-31] share the ubiquitously expressed transmembrane protein-glycoprotein-130 beta-subunit (gp130) and thus form IL-6 family cytokines. Proteins that may be important for cancerogenesis, CT-1, IL-11, IL-27, LIF, OSM, and CNTF, belong to the superfamily of IL-6. Cytokines such as IL-6, IL-11, and IL-27 are better investigated in comparison with other members of the same family of cytokines, eg, CT-1. Gp130 is one of the main receptors through which these cytokines exert their effects. The clinical implication of understanding the pathways of these cytokines in oncology is that targeted therapy to inhibit or potentiate cytokine activity may lead to remission in some cases.
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| http://dx.doi.org/10.1089/jir.2023.0103 | DOI Listing |
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