AI Article Synopsis
- - The study aimed to see if lactate oxidation impacts the C-bicarbonate signal in the awake human brain using hyperpolarized C MRI.
- - Six healthy participants underwent two MRI scans, with one set incorporating increased radiofrequency saturation of C-lactate to analyze its effects on C-bicarbonate and C-pyruvate signals across 132 brain regions.
- - Results showed that higher radiofrequency saturation of C-lactate significantly lowered C-bicarbonate signals, indicating lactate produced from injected C-pyruvate is being converted back and oxidized in the brain.
Article Abstract
Purpose: To test the hypothesis that lactate oxidation contributes to the C-bicarbonate signal observed in the awake human brain using hyperpolarized C MRI.
Methods: Healthy human volunteers (N = 6) were scanned twice using hyperpolarized C-MRI, with increased radiofrequency saturation of C-lactate on one set of scans. C-lactate, C-bicarbonate, and C-pyruvate signals for 132 brain regions across each set of scans were compared using a clustered Wilcoxon signed-rank test.
Results: Increased C-lactate radiofrequency saturation resulted in a significantly lower C-bicarbonate signal (p = 0.04). These changes were observed across the majority of brain regions.
Conclusion: Radiofrequency saturation of C-lactate leads to a decrease in C-bicarbonate signal, demonstrating that the C-lactate generated from the injected C-pyruvate is being converted back to C-pyruvate and oxidized throughout the human brain.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11225103 | PMC |
| http://dx.doi.org/10.1002/mrm.29919 | DOI Listing |
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