Chronic hepatitis C (HCV) affects up to 3.25 million children and adolescents. Early treatment of HCV in children and adolescents reduces progression to advanced liver disease and cancer. Treatment for HCV has evolved to highly effective direct acting antiviral therapy in adults and now in children ≥3 years of age. This review focuses on the role of sofosbuvir and velpatasvir (SOF/VEL), a newer treatment of children and adolescents with chronic HCV. SOF/VEL is a pangenotypic DAA with primary clearance via the liver and biliary excretion. It has been studied in children and adolescents and is approved in the US for use in children and adolescents ≥3 years of age. Although the data are currently limited, SOF/VEL has demonstrated sustained viral response rates similar to comparable DAAs in the range of 95-98%. To date, side effects have been minimal.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789568 | PMC |
| http://dx.doi.org/10.2147/TCRM.S326099 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Reduced Theta Inter-Trial Phase Coherence in Error Processing: A Marker of Neural Dysfunction in Attention Deficit Hyperactivity Disorder.
Psychophysiology
January 2025
Department of Psychology, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Cognitive control deficits and increased intra-subject variability have been well established as core characteristics of attention deficit hyperactivity disorder (ADHD), and there is a growing interest in their expression at the neural level. We aimed to study neural variability in ADHD, as reflected in theta inter-trial phase coherence (ITC) during error processing, a process that involves cognitive control. We examined both traditional event-related potential (ERP) measures of error processing (i.
View Article and Find Full Text PDFDevelopment of an American and Australian co-designed youth mental health literacy program.
Front Child Adolesc Psychiatry
June 2023
Michigan State University, East Lansing, MI, United States.
Adolescence is marked by a high prevalence of mental health concerns, with approximately 14% of young individuals receiving a diagnosis of a mental illness disorder. This figure is projected to rise in the future. However, barriers such as limited access to mental health services, a shortage of mental health professionals, and the enduring stigma surrounding mental health prevent many adolescents from seeking help, potentially resulting in long-term negative outcomes.
View Article and Find Full Text PDFGlobal trends and hotspots of type 2 diabetes in children and adolescents: A bibliometric study and visualization analysis.
World J Diabetes
January 2025
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
Background: Epidemiological surveys indicate an increasing incidence of type 2 diabetes mellitus (T2DM) among children and adolescents worldwide. Due to rapid disease progression, severe long-term cardiorenal complications, a lack of effective treatment strategies, and substantial socioeconomic burdens, it has become an urgent public health issue that requires management and resolution. Adolescent T2DM differs from adult T2DM.
View Article and Find Full Text PDFEfficacy of psychomotor therapy for children and adolescents with anxiety disorders-a systematic literature review.
Front Child Adolesc Psychiatry
January 2024
Department of Human Movement and Education, Windesheim University of Applied Sciences, Zwolle, Netherlands.
Unlabelled: Specific Phobia (SP), Generalized Anxiety Disorders (GAD), and Social Anxiety Disorder (SAD) are the most prevalent anxiety disorders in children and adolescents. Although anxiety has a major influence on the body, evidence-based treatments mainly focus on cognitive and behavioral aspects of anxiety. Body- and movement-oriented interventions, such as psychomotor therapy (PMT), address the physical aspects.
View Article and Find Full Text PDFThe SNABB ADHD treatment scale-An easy-to-use scale on treatment monitoring in childhood ADHD: A pilot study.
Front Child Adolesc Psychiatry
April 2023
Child and Adolescent Specialist Centre, Angered Hospital, SV Hospital Group, Gothenburg, Sweden.
Introduction: Information from parents and teachers are essential in the treatment monitoring of children with attention deficit hyperactivity disorder (ADHD). Rating scales are infrequently used in the treatment monitoring, and clinicians are signalling logistic barriers in the administration of rating scales in clinical settings. Here, we aimed to try out a new easy-to-use scale to facilitate information sharing between parents, teachers, and medical staff, in the treatment of childhood ADHD.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!