[Immediate results of parlodel treatment of patients with diffuse toxic goiter complicated by endocrine ophthalmopathy].

The authors reported the results of parlodel therapy of 18 patients with diffuse toxic goiter complicated by endocrine ophthalmopathy. The patients ranged in age from 24 to 59 with a period of disease from 3 months to 10 years and more. The drug was given for 6 weeks at a dose of 2.5 mg twice a day after meals, a course dose varied from 150 to 225 mg. A radioimmunoassay was used to determine T3, T4 and TTH, the patients underwent a thorough ophthalmological examination. Six weeks after parlodel therapy was initiated, a decrease in the TTH level up to normal values was observed in parallel with the regression of clinical signs of endocrine ophthalmopathy. The use of parlodel did not change considerably the level of the thyroid hormones T3 and T4.