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Decentralized research technology use in multicenter clinical research studies based at U.S. academic research centers. | LitMetric

AI Article Synopsis

  • The study explores how academic research organizations (AROs) accelerated the use of decentralization technologies in clinical research during the COVID-19 pandemic, necessitating a review of current practices.
  • It assessed 44 clinical trials coordinated by three U.S. data centers, revealing that technologies like eIRB, eSource, and Clinical Trial Management Systems were almost universally adopted, while others like telemedicine and wearables were less common.
  • The findings indicate that although there is higher adoption of these technologies than in the past, challenges remain related to institutional IT support and the need for proper infrastructure in research settings.

Article Abstract

Introduction: During the COVID-19 pandemic, research organizations accelerated adoption of technologies that enable remote participation. Now, there's a pressing need to evaluate current decentralization practices and develop appropriate research, education, and operations infrastructure. The purpose of this study was to examine current adoption of decentralization technologies in a sample of clinical research studies conducted by academic research organizations (AROs).

Methods: The setting was three data coordinating centers in the U.S. These centers initiated coordination of 44 clinical research studies during or after 2020, with national recruitment and enrollment, and entailing coordination between one and one hundred sites. We determined the decentralization technologies used in these studies.

Results: We obtained data for 44/44 (100%) trials coordinated by the three centers. Three technologies have been adopted across nearly all studies (98-100%): eIRB, eSource, and Clinical Trial Management Systems. Commonly used technologies included e-Signature (32/44, 73%), Online Payments Portals (26/44, 59%), ePROs (23/44, 53%), Interactive Response Technology (22/44, 50%), Telemedicine (19/44, 43%), and eConsent (18/44, 41%). Wearables (7/44,16%) and Online Recruitment Portals (5/44,11%) were less common. Rarely utilized technologies included Direct-to-Patient Portals (1/44, 2%) and Home Health Nurse Portals (1/44, 2%).

Conclusions: All studies incorporated some type of decentralization technology, with more extensive adoption than found in previous research. However, adoption may be strongly influenced by institution-specific IT and informatics infrastructure and support. There are inherent needs, responsibilities, and challenges when incorporating decentralization technology into a research study, and AROs must ensure that infrastructure and informatics staff are adequate.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10790101PMC
http://dx.doi.org/10.1017/cts.2023.678DOI Listing

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