Novel Pyrazolopyridine Inhibitors of Monoacylglycerol Lipase for the Treatment of Neurodegenerative Diseases and Neuroinflammation.

ACS Med Chem Lett

Arrival Discovery, LLC, 12396 World Trade Drive, San Diego, California 92128, United States.

Published: January 2024

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Article Abstract

This work highlights the use of bicyclic heterocyclic compounds as monoacylglycerol lipase inhibitors potentially in the treatment of Alzheimer's disease, Parkinson's disease, ALS, traumatic brain injury, and multiple sclerosis.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10788934PMC
http://dx.doi.org/10.1021/acsmedchemlett.3c00548DOI Listing

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