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3D scanner's potential as a novel tool for lymphedema measurement in mouse hindlimb models.
Sci Rep
January 2025
Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Lymphedema is characterized by persistent swelling due to impaired lymphatic function and presents significant challenges in both research and clinical settings. Traditional contact-based measurement techniques such as paw thickness and circumferential measurements using calipers or silk thread are useful but limited by observer variability and measurement accuracy. Non-contact methods, including various imaging techniques, offer improvements but often at higher cost and complexity.
View Article and Find Full Text PDFVirtual staining from bright-field microscopy for label-free quantitative analysis of plant cell structures.
Plant Mol Biol
January 2025
Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-Ku, Kumamoto, 860-8555, Japan.
The applicability of a deep learning model for the virtual staining of plant cell structures using bright-field microscopy was investigated. The training dataset consisted of microscopy images of tobacco BY-2 cells with the plasma membrane stained with the fluorescent dye PlasMem Bright Green and the cell nucleus labeled with Histone-red fluorescent protein. The trained models successfully detected the expansion of cell nuclei upon aphidicolin treatment and a decrease in the cell aspect ratio upon propyzamide treatment, demonstrating its utility in cell morphometry.
View Article and Find Full Text PDFPredicting and optimising outcome for biliary atresia.
Semin Pediatr Surg
January 2025
Dept of Paediatric Surgery, Kings College Hospital, London SE59RS, England, United Kingdom. Electronic address:
Biliary atresia (BA) remains a disease of significant morbidity and mortality world-wide. Early and accurate diagnosis facilitates early intervention and improves outcomes. The gold standard in diagnosing BA is a liver biopsy followed by cholangiography, usually performed intra-operatively.
View Article and Find Full Text PDFDeviant sound frequency and time stimuli in auditory oddball tasks reveal persistent aberrant brain activity in patients with psychosis and symptomatic remission.
J Psychiatr Res
January 2025
Department of Psychiatry and Clinical Psychology, Clínica Universidad de Navarra, Pamplona, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.
The detection of rare or deviant stimuli shares common brain circuits involved in temporal processing and salience, critical for cognitive control. Disruption in these processes may contribute to the mechanisms of the disease and explain cognitive deficits observed in psychosis and related disorders. We designed a neuroimaging study, using oddball task-based functional sequences (fMRI) and diffusion tensor imaging (DTI), comparing healthy controls (HC, n = 14, 7 females) and patients with stable psychosis (PSY, n = 20, 10 females).
View Article and Find Full Text PDFMultiparametric MRI-based machine learning system of molecular subgroups and prognosis in medulloblastoma.
Eur Radiol
January 2025
Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Objectives: We aimed to use artificial intelligence to accurately identify molecular subgroups of medulloblastoma (MB), predict clinical outcomes, and incorporate deep learning-based imaging features into the risk stratification.
Methods: The MRI features were extracted for molecular subgroups by a novel multi-parameter convolutional neural network (CNN) called Bi-ResNet-MB. Then, MR features were used to establish a prognosis model based on XGBoost.
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