AI Article Synopsis
- The study compares amino acid PET scans and conventional MRI to predict overall survival in patients with recurrent high grade glioma undergoing bevacizumab therapy.
- Five studies with 72 patients revealed that PET-positive patients had significantly lower median survival compared to PET-negative patients.
- The findings suggest that AA-PET is more effective than RANO MRI in predicting overall survival, with higher sensitivity and area under the curve values.
Article Abstract
Purpose: To summarize evidence on the comparative value of amino acid (AA) PET and conventional MRI for prediction of overall survival (OS) in patients with recurrent high grade glioma (rHGG) under bevacizumab therapy.
Methods: Medical databases were screened for studies with individual data on OS, follow-up MRI, and PET findings in the same patient. MRI images were assessed according to the RANO criteria. A receiver operating characteristic curve analysis was used to predict OS at 9 months.
Results: Five studies with a total of 72 patients were included. Median OS was significantly lower in the PET-positive than in the PET-negative group. PET findings predicted OS with a pooled sensitivity and specificity of 76% and 71%, respectively. Corresponding values for MRI were 32% and 82%. Area under the curve and sensitivity were significantly higher for PET than for MRI.
Conclusion: For monitoring of patients with rHGG under bevacizumab therapy, AA-PET should be preferred over RANO MRI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11043199 | PMC |
| http://dx.doi.org/10.1007/s00259-024-06601-4 | DOI Listing |
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