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The first ornithocheiromorph humerus from Wuerho (Urho), China, with a new isotopic age of the Tugulu Group.
An Acad Bras Cienc
January 2025
Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Key Laboratory of Vertebrate Evolution and Human Origins, Beijing, 100044, China.
Pterosaur remains are rare from the lowermost Cretaceous, hampering our understanding of the taxonomic and morphological diversities of pterosaurs during this period. The Lower Cretaceous Tugulu Group in Wuerho, China is renowned for hosting the Wuerho Pterosaurian Fauna (WPF), which has so far yielded numerous fossil remains of two dsungaripterid pterosaurs, Dsungaripterus weii and Noripterus complicidens. Here we report a partial ornithocheiromorph humerus from the WPF, representing a deeply divergent clade from Dsungaripteridae.
View Article and Find Full Text PDFProximity Ligation Assay to Study Oncogene-Derived Transcription-Replication Conflicts.
J Vis Exp
January 2025
Institute of Biochemistry and Molecular Biology, Hengyang Medical School, University of South China; National Health Commission Key Laboratory of Birth Defect Research and Preventio, Hunan Provincial Maternal and Child Health Care Hospital;
Both DNA replication and RNA transcription utilize genomic DNA as their template, necessitating spatial and temporal separation of these processes. Conflicts between the replication and transcription machinery, termed transcription-replication conflicts (TRCs), pose a considerable risk to genome stability, a critical factor in cancer development. While several factors regulating these collisions have been identified, pinpointing primary causes remains difficult due to limited tools for direct visualization and clear interpretation.
View Article and Find Full Text PDFConstruction of an Artificially Intelligent Model for Accurate Detection of HCC by Integrating Clinical, Radiological, and Peripheral Immunological Features.
Int J Surg
January 2025
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background: Integrating comprehensive information on hepatocellular carcinoma (HCC) is essential to improve its early detection. We aimed to develop a model with multi-modal features (MMF) using artificial intelligence (AI) approaches to enhance the performance of HCC detection.
Materials And Methods: A total of 1,092 participants were enrolled from 16 centers.
Navigating the neuroinflammatory network: insights from diverse cell models.
In Vitro Model
February 2024
IFIBYNE-UBA-CONICET, Buenos Aires, Argentina.
In this Highlights article, we present insights into the use of simple cell lines in neuroinflammation research, highlighting key findings from our recent investigations. Simple cell lines, including HEK, PC12, SHSY5Y, and N2a cells, provide valuable insights into critical signaling pathways and hidden facets of the neuroinflammatory landscape. Focusing on specific outcomes, including the impact of interleukin-6 (IL-6) and acid-sensing ion channels (ASIC1a), the study sheds light on neuroinflammatory processes.
View Article and Find Full Text PDFMachine learning prediction of hepatic encephalopathy for long-term survival after transjugular intrahepatic portosystemic shunt in acute variceal bleeding.
World J Gastroenterol
January 2025
Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou 510151, Guangdong Province, China.
Background: Transjugular intrahepatic portosystemic shunt (TIPS) is an effective intervention for managing complications of portal hypertension, particularly acute variceal bleeding (AVB). While effective in reducing portal pressure and preventing rebleeding, TIPS is associated with a considerable risk of overt hepatic encephalopathy (OHE), a complication that significantly elevates mortality rates.
Aim: To develop a machine learning (ML) model to predict OHE occurrence post-TIPS in patients with AVB using a 5-year dataset.
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