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Feasibility of Circulating Tumor DNA Analysis in Patients with Follicular Lymphoma. | LitMetric

Feasibility of Circulating Tumor DNA Analysis in Patients with Follicular Lymphoma.

Cancer Res Treat

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Published: July 2024

AI Article Synopsis

  • The study investigates the potential of using circulating tumor DNA (ctDNA) in plasma as a biomarker to predict early relapse or poor prognosis in patients with follicular lymphoma (FL) undergoing treatment.
  • Researchers analyzed plasma samples from FL patients before and during immunochemotherapy, finding significant mutations linked to survival outcomes, particularly in genes like CREBBP and TP53.
  • While ctDNA analysis shows promise for predicting disease outcomes and monitoring patient status, improvements in measurement techniques are needed for it to be clinically applicable in FL cases.

Article Abstract

Purpose: The feasibility of sequencing circulating tumor DNA (ctDNA) in plasma as a biomarker to predict early relapse or poor prognosis in patients with follicular lymphoma (FL) receiving systemic immunochemotherapy is not clear.

Materials And Methods: We sequenced DNA from cell-free plasma that was serially obtained from newly diagnosed FL patients undergoing systemic immunochemotherapy. The mutation profiles of ctDNA at the time of diagnosis and at response evaluation and relapse and/or progression were compared with clinical course and treatment outcomes.

Results: Forty samples from patients receiving rituximab-containing immunochemotherapy were analyzed. Baseline sequencing detected mutations in all cases, with the major detected mutations being KMT2C (50%), CREBBP (45%), and KMT2D (45%). The concentration of ctDNA and tumor mutation burden showed a significant association with survival outcome. In particular, the presence of mutations in CREBBP and TP53 showed poor prognosis compared with patients without them. Longitudinal analysis of ctDNA using serially collected plasma samples showed an association between persistence or reappearance of ctDNA mutations and disease relapse or progression.

Conclusion: Analysis of ctDNA mutations in plasma at diagnosis might help predict outcome of disease, while analysis during follow-up may help to monitor disease status of patients with advanced FL. However, the feasibility of ctDNA measurement must be improved in order for it to become an appropriate and clinically relevant test in FL patients.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11261198PMC
http://dx.doi.org/10.4143/crt.2023.869DOI Listing

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