A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Natural compound Sanggenon C inhibits porcine reproductive and respiratory syndrome virus replication in piglets. | LitMetric

Natural compound Sanggenon C inhibits porcine reproductive and respiratory syndrome virus replication in piglets.

Vet Microbiol

State Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, College of Veterinary Medicine, Lanzhou University, Lanzhou 730046, Gansu, China. Electronic address:

Published: March 2024

AI Article Synopsis

  • Porcine reproductive and respiratory syndrome virus (PRRSV) poses a significant threat to the global pig industry, and effective treatments are currently lacking.
  • Sanggenon C, a natural compound from mulberry root bark, has shown potential antiviral properties against PRRSV in cell cultures.
  • In recent studies with piglets, Sanggenon C demonstrated promising results by reducing viral loads, alleviating lung tissue damage, and minimizing clinical symptoms, highlighting its potential as a treatment for PRRSV.

Article Abstract

Porcine reproductive and respiratory syndrome virus is one of the main pathogens threatening the global pig industry, and there is still a lack of effective therapeutic drugs. Sanggenon C is a flavanone Diels-Alder adduct compound extracted from the root bark of the mulberry genus, which has blood pressure-reducing, anti-atherosclerotic, anti-oxidative, and anti-inflammatory effects. In our previous study, Sanggenon C was confirmed to significantly inhibit PRRSV replication in vitro. However, its antiviral potential to inhibit PRRSV infection in vivo has not been evaluated in piglets. Here, the antiviral effect of Sanggenon C was evaluated in PRRSV-challenged piglets based on assessments of rectal temperature, viral load, pathological changes of lung tissue and secretion of inflammatory cytokines. The results showed that Sanggenon C treatment relieved the clinical symptoms, reduced the viral loads in the lungs and bloods, alleviated the pathological damage of lung tissue, decreased the secretion of inflammatory cytokines, and shorten the excretion time of virus from the oral and nasal secretions and feces of piglets after PRRSV infection. The results indicated that Sanggenon C is a promising anti-PRRSV drug, which provides a new strategy for the prevention and control of PRRS in clinical practice.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vetmic.2024.109991DOI Listing

Publication Analysis

Top Keywords

porcine reproductive
8
reproductive respiratory
8
respiratory syndrome
8
syndrome virus
8
inhibit prrsv
8
prrsv infection
8
lung tissue
8
secretion inflammatory
8
inflammatory cytokines
8
sanggenon
6

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!