Considering the conventional calibration restriction of the complicated calibration procedures, narrow dynamic range, and less correlation in the calibration data, a global optimization radiometric calibration method is proposed in this paper. First, a unified database is generated by integrating different gray-level images, neutral density attenuators, integration times, and target radiations under the deduced infrared physical model. Then, the calibration coefficients are automatically learned through the relative error backward propagation network. Finally, experiments are conducted on a large-aperture ground-based infrared system to evaluate the effectiveness of the proposed method. The results indicate the proposed method can solve the problem of learning imbalance with large fluctuations of infrared radiation, ensure global measurement precision with a simpler calibration procedure, and accurately measure the internal stray radiation of the optical system.
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Sci Rep
December 2024
Bioinformatics Laboratory, College of Computing, University Mohammed VI Polytechnic, Ben Guerir, Morocco.
Hepatitis C virus (HCV) presents a significant global health issue due to its widespread prevalence and the absence of a reliable vaccine for prevention. While significant progress has been achieved in therapeutic interventions since the disease was first identified, its resurgence underscores the need for innovative strategies to combat it. The nonstructural protein NS5A is crucial in the life cycle of the HCV, serving as a significant factor in both viral replication and assembly processes.
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December 2024
Department of Civil and Environmental Engineering, University of Brasília, Brasília, 70910-900, Brazil.
Given the complexity of the behavior of mining tailings dams built by the technique of hydraulic embankments and the recurring dam ruptures globally, especially in Brazil, ensuring enhanced safety through advanced disposal techniques becomes crucial. While the co-disposal method has been extensively explored for various mineral substances, a notable gap exists in the literature concerning its application specifically to tailings and waste rock generated from phosphate mining operations. This study aims to identify the optimal ratio for a mining tailings and waste rock mixture and evaluate its mechanical behavior in comparison to individual materials.
View Article and Find Full Text PDFHere we report results of a phase 1 multi-institutional, open-label, dose-escalation trial (NCT02744287) of BPX-601, an investigational autologous PSCA-directed GoCAR-T® cell product containing an inducible MyD88/CD40 ON-switch responsive to the activating dimerizer rimiducid, in patients with metastatic pancreatic (mPDAC) or castration-resistant prostate cancer (mCRPC). Primary objectives were to evaluate safety and tolerability and determine the recommended phase 2 dose/schedule (RP2D). Secondary objectives included the assessment of efficacy and characterization of the pharmacokinetics of rimiducid.
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December 2024
State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Liquid fertilizers, particularly when integrated with precision irrigation systems, offer a more efficient and sustainable alternative to traditional solid nitrogen fertilizers. The industrial production of ammonium nitrate (NHNO) is environmentally detrimental due to its reliance on fossil fuels. This study introduces an innovative air-to-NOx-to-NHNO pathway for synthesizing liquid nitrogen fertilizer.
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November 2024
School of Science, China Pharmaceutical University, Nanjing 211198, China.
The supervision of novel psychoactive substances (NPSs) is a global problem, and the regulation of NPSs was heavily relied on identifying structural matches in established NPSs databases. However, violators could circumvent legal oversight by altering the side chain structure of recognized NPSs and the existing methods cannot overcome the inaccuracy and lag of supervision. In this study, we propose a scaffold and transformer-based NPS generation and Screening (STNGS) framework to systematically identify and evaluate potential NPSs.
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