AI Article Synopsis
- - Procalcitonin (PCT) is a biomarker that helps in diagnosing conditions like septicemia, pyemia, and stroke-related pneumonia.
- - A new sandwich-like voltammetric immunosensor was created using β-cyclodextrin and graphene to detect PCT, incorporating antibodies and a signal probe for enhanced sensitivity.
- - The developed sensor shows a very low detection limit and a wide range of PCT concentrations, making it a promising tool for detecting PCT and potentially other biomarkers.
Article Abstract
Procalcitonin (PCT) is a reliable biomarker in the early diagnosis of septicemia, pyemia and stroke-associated pneumonia. In this work, through preparing β-cyclodextrin/graphene (CD/GN) nanohybrid as carrier and amplifier simultaneously to band antibodies and probe molecules, a simple and innovative sandwich-like voltammetric immunosensor was proposed for the sensitive and effective determination of PCT. Owing to the host-guest recognition property, the antibodies of PCT can enter into the CD cavities to generate a stable complex; meanwhile, aminopyrene (AP) were introduced as the signal probe and it was adsorbed on the surface of GN via aminopyrine π-πinteraction. Based on the signal change from AP as a response signal which exhibits linearity to the concentration of PCT, a highly sensitive sandwich-type voltammetric immunosensor was developed successfully after optimizing various key parameters. The results demonstrated that the developed sensor had a considerably low detection limit (0.003 pg mL) and wide linearity of 0.01 pg mL to 20.0 ng mL. This work offered a very simple and sensitive sensing strategy for PCT and other biomarkers via altering the specific antibodies simply, showing great potential applications.
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| http://dx.doi.org/10.1007/s44211-023-00485-4 | DOI Listing |
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