AI Article Synopsis
- In kidney transplants, donor HLA antibodies increase the risk of graft loss, and the ElliPro score is used to assess donor eplets relevant to these antibodies.
- In a study of a large Dutch kidney transplant group, no significant differences in ElliPro scores were found when comparing early graft failures to long-surviving transplants.
- Ultimately, the research concluded that ElliPro scores are not effective in predicting which donor HLA antibodies may lead to early or late kidney graft loss.
Article Abstract
In kidney transplantation, donor HLA antibodies are a risk factor for graft loss. Accessibility of donor eplets for HLA antibodies is predicted by the ElliPro score. The clinical usefulness of those scores in relation to transplant outcome is unknown. In a large Dutch kidney transplant cohort, Ellipro scores of pretransplant donor antibodies that can be assigned to known eplets (donor epitope specific HLA antibodies [DESAs]) were compared between early graft failure and long surviving deceased donor transplants. We did not observe a significant Ellipro score difference between the two cohorts, nor significant differences in graft survival between transplants with DESAs having high versus low total Ellipro scores. We conclude that Ellipro scores cannot be used to identify DESAs associated with early versus late kidney graft loss in deceased donor transplants.
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| http://dx.doi.org/10.1111/tan.15297 | DOI Listing |
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Article Synopsis
- In kidney transplants, donor HLA antibodies increase the risk of graft loss, and the ElliPro score is used to assess donor eplets relevant to these antibodies.
- In a study of a large Dutch kidney transplant group, no significant differences in ElliPro scores were found when comparing early graft failures to long-surviving transplants.
- Ultimately, the research concluded that ElliPro scores are not effective in predicting which donor HLA antibodies may lead to early or late kidney graft loss.
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