AI Article Synopsis
- The emergence of SARS-CoV-2 has led to the COVID-19 pandemic, significantly impacting society and global health.
- The virus spreads rapidly and evolves continually, posing ongoing threats to public health.
- Recent research has revealed critical insights into the SARS-CoV-2 life cycle, including gene functions, virus-host interactions, and new host-cell factors essential for the virus's replication.
Article Abstract
The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected our society. The rapid spread and continuous evolution of new SARS-CoV-2 variants continue to threaten global public health. Recent scientific advances have dissected many of the molecular and cellular mechanisms involved in coronavirus infections, and large-scale screens have uncovered novel host-cell factors that are vitally important for the virus life cycle. In this Review, we provide an updated summary of the SARS-CoV-2 life cycle, gene function and virus-host interactions, including recent landmark findings on general aspects of coronavirus biology and newly discovered host factors necessary for virus replication.
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| http://dx.doi.org/10.1038/s41579-023-01003-z | DOI Listing |
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