Effects of carbohydrate availability on cycling endurance at the maximal lactate steady state.

Am J Physiol Regul Integr Comp Physiol

Faculty of Kinesiology, Human Performance Lab, University of Calgary, Alberta, Canada.

Published: March 2024

The impacts of carbohydrate (CHO) availability on time to task failure (TTF) and physiological responses to exercise at the maximal lactate steady state (MLSS) have not been studied. Ten participants (3 females, 7 males) completed this double-blinded, placebo-controlled study that involved a ramp incremental test, MLSS determination, and four TTF trials at MLSS, all performed on a cycle ergometer. With the use of a combination of nutritional (CHO, 7 g/kg, and placebo, PLA, 0 g/kg drinks) and exercise interventions [no exercise (REST) and glycogen-reducing exercise (EX)], the four conditions were expected to differ in preexercise CHO availability (REST > REST > EX > EX). TTF at MLSS was not improved by CHO loading, as REST (57.1 [16.6] min) and REST (57.1 [15.6] min) were not different ( = 1.00); however, TTF was ∼50% shorter in EX conditions compared with REST conditions on average ( < 0.05), with EX (39.1 [9.2] min) ∼90% longer than EX (20.6 [6.9] min; < 0.001). There were effects of condition for all perceptual and cardiometabolic variables when compared at isotime ( < 0.05) and task failure (TF; < 0.05), except for ventilation, perceptual responses, and neuromuscular function measures, which were not different at TF ( > 0.05). Blood lactate concentration was stable in all conditions for participants who completed 30 min of exercise. These findings indicate that TTF at MLSS is not enhanced by preexercise CHO supplementation, but recent intense exercise decreases TTF at MLSS even with CHO supplementation. Extreme fluctuations in diet and strenuous exercise that reduce CHO availability should be avoided before MLSS determination. Carbohydrate (CHO) loading did not increase participants' ability to cycle at their maximal lactate steady state (MLSS); however, performing a glycogen depletion task the evening before cycling at MLSS reduced the time to task failure, even when paired with a high dose of CHO. These diet and exercise interventions influenced blood lactate concentration ([BLa]) but not the stability of [BLa]. Activities that reduce CHO availability should be avoided before MLSS determination.

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpregu.00178.2023DOI Listing

Publication Analysis

Top Keywords

cho availability
16
maximal lactate
12
lactate steady
12
steady state
12
task failure
12
mlss determination
12
ttf mlss
12
cho
10
mlss
10
carbohydrate cho
8

Similar Publications

Traumatic injury remains a leading cause of death worldwide, with traumatic bleeding being one of its most critical and fatal consequences. The use of whole-body computed tomography (WBCT) in trauma management has rapidly expanded. However, interpreting WBCT images within the limited time available before treatment is particularly challenging for acute care physicians.

View Article and Find Full Text PDF

Cases for a disease can be defined broadly using diagnostic codes, or narrowly using gold-standard confirmation that often is not available in large administrative datasets. These different definitions can have significant impacts on the results and conclusions of studies. We conducted this study to assess how using melanoma phecodes versus histologic confirmation for invasive or in situ melanoma impacts the results of a genome-wide association study (GWAS) using the Million Veteran Program.

View Article and Find Full Text PDF

Dynamic Importance of Genomic and Clinical Risk for Coronary Artery Disease Over the Life Course.

Circ Genom Precis Med

January 2025

Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston. (S.M.U., K.P., B.T., A.C.F., P.N.).

Background: Earlier identification of high coronary artery disease (CAD) risk individuals may enable more effective prevention strategies. However, existing 10-year risk frameworks are ineffective at earlier identification. We sought to understand how the variable importance of genomic and clinical factors across life stages may significantly improve lifelong CAD event prediction.

View Article and Find Full Text PDF

Socioeconomic Inequity in Access to Medical and Long-Term Care Among Older People.

Int J Equity Health

January 2025

Department of Health Management and Policy, School of Public Health, University of Michigan, Michigan, USA.

Background: Ensuring equitable access to medical and long-term care (LTC) is critical to enable older people to maintain their health and well-being even after they undergo a decline in their intrinsic capacity.

Methods: We used data from five waves of the National Survey of the Japanese Elderly, conducted between 2002 and 2021, to assess gradients in access to medical care and LTC by income and education among Japanese individuals aged 60 years and above. Specifically, we assessed self-reported unmet needs for medical care and LTC, and public LTC use, and estimated the concentration indices (CI) to evaluate the degree of inequality and inequity.

View Article and Find Full Text PDF

Advances in cancer genomics and precision oncology.

Genes Genomics

January 2025

Department of Smart Farm and Agricultural Industry, Kangwon National University, Chuncheon, 24341, Republic of Korea.

Background: Next-generation sequencing has revolutionized genome science over the last two decades. Indeed, the wealth of sequence information on our genome has deepened our understanding on cancer. Cancer is a genetic disease caused by genetic or epigenetic alternations that affect the expression of genes that control cell functions, particularly cell growth and division.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!