AI Article Synopsis
- Photoacoustic Doppler flowmetry provides important quantitative data on blood flow and vascular details for evaluating rectal cancer.
- Researchers aimed to enhance this technique using an acoustic resolution photoacoustic microscopy (AR-PAM) system for detailed blood perfusion analysis.
- Successful validation in lab studies indicates that this method can effectively assess treatment responses and differentiate between residual cancer and healthy tissue post-chemoradiation.
Article Abstract
Significance: Photoacoustic Doppler flowmetry offers quantitative blood perfusion information in addition to photoacoustic vascular contrast for rectal cancer assessment.
Aim: We aim to develop and validate a correlational Doppler flowmetry utilizing an acoustic resolution photoacoustic microscopy (AR-PAM) system for blood perfusion analysis.
Approach: To extract blood perfusion information, we implemented AR-PAM Doppler flowmetry consisting of signal filtering and conditioning, A-line correlation, and angle compensation. We developed flow phantoms and contrast agent to systemically investigate the flowmetry's efficacy in a series of phantom studies. The developed correlational Doppler flowmetry was applied to images collected during AR-PAM for post-treatment rectal cancer evaluation.
Results: The linearity and accuracy of the Doppler flow measurement system were validated in phantom studies. Imaging rectal cancer patients treated with chemoradiation demonstrated the feasibility of using correlational Doppler flowmetry to assess treatment response and distinguish residual cancer from cancer-free tumor bed tissue and normal rectal tissue.
Conclusions: A new correlational Doppler flowmetry was developed and validated through systematic phantom evaluations. The results of its application to patients suggest it could be a useful addition to photoacoustic endoscopy for post-treatment rectal cancer assessment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10787588 | PMC |
| http://dx.doi.org/10.1117/1.JBO.29.S1.S11517 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Changes in the Microcirculation and Physiologic Perfusion Dynamics of Free DIEP Flaps in the First 72 h After Breast Reconstruction.
J Clin Med
January 2025
Division of Hand, Plastic and Aesthetic Surgery, University Hospital, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.
The autologous reconstruction of the female breast using a microsurgical DIEP flap is a reliable and safe method. To detect impairments early and preserve the microvascular flap through timely revision, a better understanding of physiologic perfusion dynamics is necessary. This exploratory study examines changes in microcirculation in free DIEP flaps within the first 72 h after vascular anastomosis using laser Doppler flowmetry and white-light spectrophotometry.
View Article and Find Full Text PDFAdvanced Lasers and Their Applications in Dentistry.
Dent J (Basel)
January 2025
Faculty of Dentistry, The University of Hong Kong, Hong Kong 999077, China.
The development of laser technology has revolutionized dentistry, offering complementary and alternative approaches to traditional techniques. Lasers have been successfully integrated into various dental procedures, enhancing treatment outcomes and patient care. Several types of lasers can increase the acid resistance of enamel, thus preventing caries.
View Article and Find Full Text PDFChanges in microcirculation variables in an acute endotoxaemic equine model.
Equine Vet J
January 2025
Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
Background: Microcirculation is the essential link between macrocirculation and cellular metabolism.
Objectives: To test our hypotheses that microcirculation variables will show a heterogeneous flow pattern during experimental endotoxaemia, and that fluid therapy and noradrenaline (NA) infusion will normalise altered microcirculation variables.
Study Design: In vivo experiments.
Sex and age-related day-to-day variability in the skin microcirculation during post-occlusive reactive hyperemia.
Microvasc Res
January 2025
Primary Health Care Center, Department of Health, Medicine and Caring Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden; Wallenberg Centre for Molecular Medicine, Linköping University, Linköping, Sweden. Electronic address:
Introduction: Little is known about the day-to-day variability of different skin microcirculation parameters, and how this variability is influenced by age and sex. The aim was to examine the day-to-day variability of microcirculatory parameters in relation to age and sex.
Methods: The cutaneous microcirculation was measured using a fiber optic probe integrating laser Doppler flowmetry (LDF) and diffuse reflectance spectroscopy (DRS) to measure oxygen saturation, red blood cell (RBC) tissue fraction, speed-resolved and conventional perfusion.
Objective: Evaluation of the effectiveness of vestibuloplasty according to microhemodynamics and oxygenation in the mucous membrane of the alveolar ridge.
Materials And Methods: To achieve this goal, a clinical and functional study was carried out in the mucous membrane of the alveolar ridge after vestibuloplasty in 80 patients (35 men and 45 women) aged from 18 to 65 years, average age 41.5±1.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!