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Polymorphisms in and genes modify risk for inflammatory bowel disease. | LitMetric

Polymorphisms in and genes modify risk for inflammatory bowel disease.

Ann Gastroenterol

Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Greece (Evangelia Legaki, Tilemachos Koutouratsas, Charalampos Theocharopoulos, Vivian Lagkada, Maria Gazouli).

Published: December 2023

AI Article Synopsis

Article Abstract

Background: Inflammatory bowel disease (IBD) seems to arise from an interplay between genetic and environmental factors. and genes code for 2 members of the C-type lectin receptor superfamily, which participate in the immune response against various pathogens, mediating inflammatory signaling. polymorphisms have been linked to the risk of Crohn's disease (CD), whereas has been implicated in fungal dysbiosis, chemically induced colitis in mice and undertreated ulcerative colitis (UC) in humans. This study aimed to explore how specific and polymorphisms contribute to the development of CD and UC.

Methods: One hundred twelve CD patients, 94 UC patients and 164 sex- and age- matched healthy individuals were genotyped for the single nucleotide polymorphisms rs2078178 and rs16910631 of the gene, and rs1285933 of the gene.

Results: The rs2078178 AA genotype was more frequent in UC patients compared to healthy individuals, The rs16910631 CT genotype was significantly associated with UC risk compared to healthy individuals, while there was no statistical correlation with CD. The rs1285933 GA genotype was found to be protective against UC and CD, and the AA genotype against CD. Carriers of the rs1285933 A allele appeared to have reduced susceptibility to CD, implying that the presence of the A allele could be protective against CD development.

Conclusions: This is the first study to correlate the rs1285933 polymorphism with the risk for UC. The rs2078178 AA genotype and the rs16910631 CT could be promising biomarkers for UC susceptibility.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10785015PMC
http://dx.doi.org/10.20524/aog.2024.0843DOI Listing

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