Development of a glass-based imaging phantom to model the optical properties of human tissue.

The fabrication of a stable, reproducible optical imaging phantom is critical to the assessment and optimization of optical imaging systems. We demonstrate the use of an alternative material, glass, for the development of tissue-mimicking phantoms. The glass matrix was doped with nickel ions to approximate the absorption of hemoglobin. Scattering levels representative of human tissue were induced in the glass matrix through controlled crystallization at elevated temperatures. We show that this type of glass is a viable material for creating tissue-mimicking optical phantoms by providing controlled levels of scattering and absorption with excellent optical homogeneity, long-term stability and reproducibility.