Severe Ulcerative Colitis Complicated by Malakoplakia Resulting in Proctocolectomy.

ACG Case Rep J

Division of Gastroenterology, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

Published: January 2024

We report a 45-year-old man with medically refractory ulcerative colitis with superimposed colonic malakoplakia, presumed related to chronic use of azathioprine and biologics. This is the first reported case of malakoplakia in a patient requiring high doses of combination therapy. Treatment of malakoplakia is not standardized, but can involve systemic antibiotics, or surgical resection, which in this case resulted in proctocolectomy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10786587PMC
http://dx.doi.org/10.14309/crj.0000000000001257DOI Listing

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