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| http://dx.doi.org/10.1097/MS9.0000000000001495 | DOI Listing |
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A blood test measuring DNA methylation of BCAT1 and IKZF1 for detection of lung adenocarcinoma.
Cancer Treat Res Commun
September 2024
Cancer Impact Program, Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia. Electronic address:
Background: Colorectal (CRC) and lung adenocarcinoma share many genetic and pathological similarities. A circulating tumor DNA (ctDNA) test for CRC may also be useful for detection of lung adenocarcinoma. This study determined if a methylated BCAT1/IKZF1 ctDNA test for CRC can be used for detection of lung adenocarcinoma.
View Article and Find Full Text PDF, and : methylated DNA biomarkers for detection of pan-gastrointestinal adenocarcinomas.
Biomarkers
June 2024
Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, South Australia.
Introduction: Methylated circulating tumour DNA (ctDNA) blood tests for (COLVERA) and (Epi proColon) are used to detect colorectal cancer (CRC). However, there are no ctDNA assays approved for other gastrointestinal adenocarcinomas. We aimed to characterize and methylation in different gastrointestinal adenocarcinoma and non-gastrointestinal tumours to determine if these validated CRC biomarkers might be useful for pan-gastrointestinal adenocarcinoma detection.
View Article and Find Full Text PDFEvaluating the Role of Methylated Circulating Tumor DNA in Combination With Pathological Prognostic Factors for Predicting Recurrence of Colorectal Cancer.
Biomark Insights
February 2024
Cancer Research, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia.
Background: Colorectal cancer (CRC) has a high rate of recurrence, in particular for advanced disease, but prognosis based on staging and pathology at surgery can have limited efficacy. The presence of circulating tumor DNA (ctDNA) at diagnosis could be used to improve the prediction for disease recurrence.
Objectives: To assess the impact of detecting methylated ctDNA at diagnosis in combination with demographic, lifestyle, clinical factors and tumor pathology, to assess predictive value for recurrence.
Methylated BCAT1/IKZF1 DNA: a breakthrough in colorectal cancer diagnosis?
Ann Med Surg (Lond)
January 2024
S.R. Sanjeevani Hospital, Siraha, Nepal.
Diagnostic value of methylated branched chain amino acid transaminase 1/IKAROS family zinc finger 1 for colorectal cancer.
World J Gastroenterol
September 2023
Clinical Medical College, Chengdu Medical College, Chengdu 610500, Sichuan Province, China.
Background: The diagnostic value of combined methylated branched chain amino acid transaminase 1 (BCAT1)/IKAROS family zinc finger 1 (IKZF1) in plasma for colorectal cancer (CRC) has been explored since 2015. Recently, several related studies have published their results and showed its diagnostic efficacy.
Aim: To analyze the diagnostic value of methylated BCAT1/IKZF1 in plasma for screening and postoperative follow-up of CRC.
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