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Glycosylation Pathways Targeted by Deregulated miRNAs in Autism Spectrum Disorder.
Int J Mol Sci
January 2025
Child Neuropsychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95124 Catania, Italy.
Autism Spectrum Disorder (ASD) is a complex condition with a multifactorial aetiology including both genetic and epigenetic factors. MicroRNAs (miRNAs) play a role in ASD and may influence metabolic pathways. Glycosylation (the glycoconjugate synthesis pathway) is a necessary process for the optimal development of the central nervous system (CNS).
View Article and Find Full Text PDFEffectiveness of artificially planted mangroves on remediation of metals released from ship-breaking activities.
Mar Pollut Bull
January 2025
Department of Fisheries and Marine Science, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh; School of Engineering and Built Environment, Griffith University, Brisbane, QLD, Australia; East Coast Environmental Research Institute, Universiti Sultan Zainal Abidin, Gong Badak Campus, 21300 Kuala Nerus, Terengganu Darul Iman, Malaysia. Electronic address:
The pervasive and escalating issue of toxic metal pollution has gathered global attention, necessitating the exploration of innovative ecological strategies like phytoremediation. This study explored the extent of potentially toxic metal contamination status and the effectiveness of three planted mangrove species (Avicennia marina, Bruguiera gymnorhiza,and Excoecaria agallocha) in phytoremediation efforts to reduce pollution level. The results indicated that the mean concentrations of elements in the sediment of the area followed a descending sequence: Fe (27,136.
View Article and Find Full Text PDFAmyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer's disease.
Sci Transl Med
January 2025
Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, 81377 Munich, Germany.
In Alzheimer's disease (AD), amyloid-β (Aβ) triggers the aggregation and spreading of tau pathology, which drives neurodegeneration and cognitive decline. However, the pathophysiological link between Aβ and tau remains unclear, which hinders therapeutic efforts to attenuate Aβ-related tau accumulation. Aβ has been found to trigger neuronal hyperactivity and hyperconnectivity, and preclinical research has shown that tau spreads across connected neurons in an activity-dependent manner.
View Article and Find Full Text PDFAssociation of volatile organic compound metabolites with hearing loss: unveiling their potential mechanism and intervention target.
Environ Sci Process Impacts
January 2025
Department of Otorhinolaryngology, No. 971 Hospital of People's Liberation Army Navy, Qingdao 266000, Shandong Province, China.
Hearing loss (HL) is an otolaryngology disease susceptible to environmental pollutants. Volatile organic compounds (VOCs), as a class of chemical pollutants with evaporation propensity, pose a great threat to human health. However, the association between VOCs and HL remains unclear.
View Article and Find Full Text PDFComprehensive bioinformatics analysis identifies hub genes associated with immune cell infiltration in early-onset schizophrenia.
BMC Psychiatry
January 2025
The Fifth Hospital of Shanxi Medical University, The Fifth Clinical Medical College of Shanxi Medical University, Shanxi Provincial People's Hospital, Taiyuan, 030032, China.
Background: Early-onset schizophrenia (EOS) occurs between the ages of 13 and 17 years, and neurobiological factors leading to cognitive deficits and psychotic symptoms with varying degrees of positive and negative symptoms. Numerous studies have demonstrated a broad link between immune dysregulation and the central nervous system in EOS, and its pathogenesis involves immune dysfunction, but the exact biological mechanisms have not been elucidated. This study employs immune infiltration analysis and bioinformatics to unveil the pathogenic mechanisms of EOS and identify potential diagnostic biomarkers, aiming for more precise clinical interventions.
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