Background: Degenerative spine disease is one of the largest causes of disability worldwide and has a multifactorial aetiology. Determining the leading causes of this multifactorial disease could help create new treatment approaches.
Purpose: Study the impact of degenerative changes in the paraspinal muscles caused by local (prolonged compression) or systemic (high-fat diet) factors on the structure of the intervertebral discs (IVDs) and facet joints of the lumbar spine in rats.
Methods: The study was conducted using two animal models to create degenerative changes in the paraspinal muscles of 10 white laboratory rats for 90 days and five control rats: 1) high-fat diet model (model 1) involved keeping the rats on a high calorie diet; 2) compression model (model 2) involved binding the paraspinal muscles from L2 to S1 using non-absorbable sutures. Histological analysis for the facet joints and IVDs of rats (at the L1-L4 level) with semi-quantitative analysis of the structure conducted used by degeneration grading system for IVDs and cartilage degeneration score (OARSI) for facet joint.
Results: In both models, 90 days after the experiment, the degenerative changes observed in the rats' IVDs were more severe in the annulus fibrosus than in the nucleus pulposus. The height of the IVD in model 1 did not differ from the control group, but in the model 2 was 1.3 times greater (p < 0.001) compared with control. Degenerative changes in the IVD were scored out 5.3 ± 1.7 in model 1 and 5.32 ± 2.1 in model 2 of a possible 16. The height of the articular cartilage of the facet joints was smaller by 1.5 times (p < 0.001) and 1.4 times (p < 0.001) in model 1 and model 2, respectively, compared to the control. Degenerative changes of facet joint were scored out 3.7 ± 0.6 in model 1 and 3.8 ± 0.6 in model 2 of five points according to the cartilage degeneration score.
Conclusions: It was determined that rats who had structural changes in the lumbar paraspinal muscles as a result of being kept on a high-fat diet or subjected to prolonged compression for 90 days, showed degenerative changes in intervertebral discs and osteoarthritis in facet joints of lumbar spine.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10785363 | PMC |
| http://dx.doi.org/10.1186/s13018-024-04548-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Introduction: Increased fatty infiltration of the paraspinal muscles (PM) has been recognized as a sign of decreased muscle quality in patients with degenerative disc disease. However, whether fatty infiltration is a consequence of a neurogenic process due to spinal nerve root compression has not yet been determined.
Objective: To investigate the correlation between fatty infiltration of the paraspinal muscles (PM) and neurogenic remodeling of motor unit action potentials (MUAPs) in patients with lumbar radiculopathy.
Biomechanical analysis of scoliosis correction under the influence of muscular and external forces.
J Clin Neurosci
December 2024
Institute of Mechanical Engineering, Dalian Jiaotong University, Dalian 116028, Liaoning, China.
(1) Background: External force orthopedics and the strengthening of paraspinal muscles through exercise are common orthopedic methods for adolescent scoliosis, yet the synergetic mechanism of the two in orthopedic correction remains unclear. (2) Methods: A three-dimensional finite element model of the scoliotic spine was established to accurately simulate the mechanical properties of tissues such as the spine, intervertebral discs, and ribs. By applying external forces in different directions to the scoliosis model, the orthopedic effects of these forces on scoliosis were analyzed.
View Article and Find Full Text PDFEffects of age/gender profiles and physical activity level on symmetry of lumbar muscle activation in pain-free older adults during various spinal movements.
Gait Posture
December 2024
Department of Orthopedic Surgery, Division of Orthopedic Research, Mayo Clinic, Rochester, MN, USA. Electronic address:
Background: Back muscles simultaneously drive spinal movements and stabilize the trunk. Paraspinal muscle activity is presumed to be symmetric and gender-insensitive, and more activated with aging to protect the spine during functional tasks.
Research Question: Does over-activated and asymmetric behaviors exist in the pain-free elderly population which is affected by their physical activity levels?
Methods: Forty healthy participants (aged 64.
Quantitative observation based on magnetic resonance imaging: the effects of marathon running on lumbar vertebrae, paraspinal muscles, and lumbar disc components.
Quant Imaging Med Surg
December 2024
Department of Radiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Background: Lumbar spine injuries and lumbar disc degeneration are common spinal health problems that seriously affect people's quality of life and efficiency at work. Marathon running enhances skeletal muscle strength and endurance, and promotes increased bone mineral density. This study aimed to investigate the effects of marathon running on the lumbar spine and surrounding tissue components.
View Article and Find Full Text PDFAssociation between modifiable and nonmodifiable risk factors with paralumbar muscle health in patients with lower back pain.
N Am Spine Soc J
December 2024
Northwell Health Long Island Jewish Medical Center, Department of Orthopedic Surgery, 270-05 76th Avenue, Queens, NY 11040, United States.
Background: Prior studies have linked sarcopenia and fat infiltration in paraspinal muscles with lumbar pain, spinal pathology, and adverse postoperative outcomes in lumbar spine surgery. A recent magnetic resonance imaging (MRI)-based method for assessing muscle health, incorporating parameters such as Goutallier Classification (GC) and the Paralumbar Muscle Cross-Sectional Area to Body Mass Index ratio (PL-CSA/BMI), has shown that higher muscle grades correlate with significant improvements in patient-reported outcomes. Despite these advancements, there is limited research on the associations between paralumbar muscle health and factors such as age, BMI, walking tolerability, and spondylolisthesis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!