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Until the beginning of the century, bleeding management was similar in elective surgeries or exsanguination scenarios: clotting tests were used to guide blood product orders and, while awaiting these results, an aggressive resuscitation with crystalloids was recommended. The high mortality rate in severe hemorrhages managed with this strategy endorsed the need for a special resuscitation plan. As a result, modifications were recommended to develop a new clinical approach to these patients, called "Damage Control Resuscitation".
View Article and Find Full Text PDFPolarization-resolved transmission matrices of specialty optical fibers.
Rev Sci Instrum
December 2024
OFS Laboratories, 19 Schoolhouse Road, Somerset, New Jersey 08873, USA.
Transmission matrix measurements of multimode fibers are now routinely performed in numerous laboratories, enabling control of the electric field at the distal end of the fiber and paving the way for the potential application to ultrathin medical endoscopes with high resolution. The same concepts are applicable to other areas, such as space division multiplexing, targeted power delivery, fiber laser performance, and the general study of the mode coupling properties of the fiber. However, the process of building an experimental setup and developing the supporting code to measure the fiber's transmission matrix remains challenging and time consuming, with full details on experimental design, data collection, and supporting algorithms spread over multiple papers or lacking in detail.
View Article and Find Full Text PDFConduction System Pacing Following a Double Switch Operation for Congenitally Corrected Transposition of the Great Arteries.
Pacing Clin Electrophysiol
December 2024
Heart Rhythm Centre, Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
The use of conduction system pacing (CSP) in adults with congenital heart disease (CHD) is growing, however data remain limited. In patients with congenitally corrected transposition of the great arteries following the double switch operation, existing CSP tools and techniques require modification to allow for the anterior displacement of the atrioventricular node and proximal conduction system in addition to navigating the tortuous route of the atrial redirection. We report the successful use of CSP focusing on the technique of delivery tool modification to allow stability on the basal septum for deployment to the area of the distal His bundle and proximal left bundle branch.
View Article and Find Full Text PDFStructure of subcortico-cortical tracts in middle-aged and older adults with autism spectrum disorder.
Cereb Cortex
December 2024
Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.
Middle-aged and older adults with autism spectrum disorder may be susceptible to accelerated neurobiological changes in striato- and thalamo-cortical tracts due to combined effects of typical aging and existing disparities present from early neurodevelopment. Using magnetic resonance imaging, we employed diffusion-weighted imaging and automated tract-segmentation to explore striato- and thalamo-cortical tract microstructure and volume differences between autistic (n = 29) and typical comparison (n = 33) adults (40 to 70 years old). Fractional anisotropy, mean diffusivity, and tract volumes were measured for 14 striato-cortical and 12 thalamo-cortical tract bundles.
View Article and Find Full Text PDFHow Do Bundled Payment Initiatives Account for Differences in Patient Risk Profile? A Systematic Review.
Value Health
December 2024
Department of Health Systems & Insurance, Erasmus School of Health Policy & Management (ESHPM), Rotterdam, South-Holland, The Netherlands; Department of Health Systems & Insurance, Erasmus Centre for Health Economics Rotterdam (EsCHER), Rotterdam, South-Holland, The Netherlands.
Objectives: Bundled payments (BPs) are increasingly being adopted to enable the delivery of high-value care. For BPs to reach their goals, accounting for differences in patient risk profile (PRP) predictive of spending is crucial. However, insight is lacking into how this is done in practice.
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