AI Article Synopsis
- The study investigates the use of diuretics in treating bronchopulmonary dysplasia (BPD), a respiratory condition in premature infants, to evaluate their effectiveness.
- A systematic review was conducted, analyzing 13 studies from various databases, focusing on combinations of diuretics like spironolactone and furosemide and their impact on lung function.
- Results indicate that the effectiveness of diuretics for BPD is still unclear due to limited high-quality studies, suggesting a need for more rigorous randomized controlled trials to assess their safety and efficacy.
Article Abstract
Aim: Bronchopulmonary dysplasia (BPD), a respiratory complication associated with neonatal prematurity, presents opportunities for pharmacological intervention due to its contributing risk factors. Despite diuretics' controversial usage in BPD treatment and varying institutional practices, this review aims to consolidate evidence from clinical trials regarding diuretic use in BPD.
Methods: We conducted a systematic review following PRISMA guidelines, searching EMBASE, Medline, Web of Science and CINAHL databases (PROSPERO 2022: CRD42022328292). Covidence facilitated screening and data extraction, followed by analysis and formatting in Microsoft Excel.
Results: Among 430 screened records, 13 were included for analysis. Three studies assessed spironolactone and chlorothiazide combinations, two studied spironolactone and hydrochlorothiazide, while eight examined furosemide. All studies evaluated drug effects on dynamic pulmonary compliance and pulmonary resistance, serving as comparative measures in our review.
Conclusion: Diuretics' effectiveness in treating bronchopulmonary dysplasia remains uncertain. The limited number of identified randomised controlled trials (RCTs) hampers high-level evidence-based conclusions when applying the Population, Intervention, Comparison, Outcome (PICO) approach. Conducting large prospective studies of good quality could provide more definitive insights, but the rarity of outcomes and eligible patients poses challenges. Further research, primarily focusing on RCTs assessing diuretics' safety and efficacy in this population, is warranted.
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| http://dx.doi.org/10.1111/apa.17093 | DOI Listing |
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