AI Article Synopsis
- * Skin biopsies from patients with PPP (40) and pompholyx (22) were analyzed, revealing that K5 expression was significantly higher in PPP and K9 was more present near pompholyx vesicles.
- * The findings indicate that PPP and pompholyx show different expression profiles for certain proteins, which could assist in differentiating between the two conditions in clinical practice.
Article Abstract
Background: Palmoplantar pustulosis (PPP) and pompholyx are chronic diseases characterized by pustules and vesicles on the palms and soles. These disorders often have similar clinicopathological features, which lead to diagnostic difficulties. We aimed to investigate the expression patterns of keratins and involucrin in PPP and pompholyx using immunohistochemical staining.
Methods: Skin biopsies from patients with PPP (n = 40) and pompholyx (n = 22) were immunohistochemically analyzed for Keratin 5, 9, 14, and involucrin expression.
Results: K5 expression was higher in PPP than in pompholyx, with diffusely positive expression in the basal, spinous, and granular layers. K14 expression did not differ between groups. K9 expression was observed near the pompholyx vesicle (P = 0.014) and stratum spinosum (P < 0.001) but was almost absent around PPP pustules. Involucrin expression was diffused around the PPP pustules and partially around the pompholyx vesicles, but without statistical significance (P = 0.123). Involucrin expression was elevated in the basal layer of the PPP compared with that in the pompholyx (P = 0.023).
Conclusion: PPP and pompholyx exhibited distinctive differentiation in the expression of K5, K9, and involucrin.
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| http://dx.doi.org/10.1111/ijd.17018 | DOI Listing |
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