AI Article Synopsis
- The study looked at patients with pancreatic cancer who were supposed to have surgery to remove their tumors and focused on how often those surgeries were completed.
- Out of 681 patients, most were able to have their surgeries, but some couldn’t because the cancer spread more than expected or was too difficult to remove.
- Patients who did have surgery lived longer (around 30-36 months) compared to those who couldn’t have the surgery, who lived about a year.
Article Abstract
Objective: To investigate resection/exploration ratios (RER), reasons for omission of pancreatectomy, and survival outcomes in patients undergoing surgical exploration with resection intent for pancreatic ductal adenocarcinoma (PDAC).
Summary Background Data: While surgical indications for PDAC are expanding, information about intraoperative attrition is lacking.
Methods: The RER was calculated in PDAC patients undergoing exploration from 2018 through 2020. Factors associated with uncompleted resection and survival were identified using multivariable models.
Results: In total, 681 patients were included. Upfront explorations were 296 (43.7%), and post-neoadjuvant explorations were 385 (56.3%). The overall RER was 89.7% (90.5% in the upfront setting and 89.1% post-neoadjuvant treatment). In this latter subgroup, the RER decreased from 96.1% in resectable disease to 86.6% in borderline resectable disease and 61.9% in locally advanced disease. The primary reasons for uncompleted resection were occult metastases in presumed resectable/borderline resectable disease (without difference between upfront and post-neoadjuvant operations) and local unresectability in locally advanced disease. No preoperative variable was associated with uncompleted resection in upfront explorations, while anatomical staging informed the likelihood of surgical attrition following neoadjuvant treatment. Uncompleted resection was invariably associated with a median survival of around one year. The median post-pancreatectomy survival was 36.9 months in the upfront setting and 29.5 months following neoadjuvant treatment. The median survival from diagnosis in patients receiving post-neoadjuvant resection was 34.5 months.
Conclusions: This analysis provided contemporary information about resection rates, reasons for intraoperative attrition, and survival outcomes in the entire spectrum of PDAC patients selected for surgical exploration at an experienced institution.
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| http://dx.doi.org/10.1097/SLA.0000000000006197 | DOI Listing |
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