AI Article Synopsis
- The study aimed to evaluate the effectiveness of combining intra-peritoneal dexamethasone with bupivacaine versus using bupivacaine alone for pain relief after laparoscopic cholecystectomy.
- 84 patients were randomly assigned to receive either a mix of bupivacaine and dexamethasone or bupivacaine only, and pain levels were assessed using the visual analogue scale (VAS) and rescue analgesic consumption.
- Results showed that the group receiving dexamethasone experienced significantly lower pain levels, used less rescue analgesic, and took longer to require their first dose of pain relief compared to the bupivacaine-only group.
Article Abstract
Background And Aims: Laparoscopy is associated with acute pain. We compared the effectiveness of intra-peritoneal dexamethasone with bupivacaine versus bupivacaine in patients undergoing laparoscopic cholecystectomy for postoperative analgesia.
Methods: This randomised study was conducted after approval from the institutional ethics committee and 84 patients were randomly allocated into bupivacaine with dexamethasone group (BD) (received 40 mL of 0.25% bupivacaine with 16 mg dexamethasone), and bupivacaine group (BB) (received 40 mL of 0.25% bupivacaine intra-peritoneally). Data analysis was done using R version 4.2.1. The visual analogue scale (VAS) score, total rescue analgesic dose, and time required for the first analgesic between groups were compared using the Wilcoxon rank sum test or -test appropriately.
Results: VAS score was significantly lower in the BD group compared to the BB group until 2 h post-operatively with a mean difference of - 1.0 (95% confidence interval [CI] -1.5, -0.53), < 0.001. The total rescue analgesic dose consumed was lower in the BD group (60.71 mg [29.80]) compared to the BB group (73.20 mg [11.57]) with a mean difference of - 12.5 mg (95% CI - 22.3, -2.68), = 0.013. In addition, the time taken for the requirement of the first rescue analgesic was significantly longer in the BD group (417.1 min [276.0]) compared to the BB group (219.4 min [226.1]) with a mean difference of 197.7 (95% CI 75, 320), = 0.002.
Conclusion: Intra-peritoneal instillation of 16 mg dexamethasone with 0.25% bupivacaine in laparoscopic cholecystectomy significantly reduces post-operative pain and requirement of rescue analgesic compared to 0.25% bupivacaine alone.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10779981 | PMC |
| http://dx.doi.org/10.4103/ija.ija_275_23 | DOI Listing |
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