A Case of Nosocomial Coinfection of SARS-CoV-2 and Influenza A Virus in a Hospitalized Patient with Acute Myocardial Infarction.

Background: Inpatients in cardiovascular medicine departments often have complicated conditions, long hospital stays, and a high risk of nosocomial infection. Good infection control is of great importance for the treatment and rehabilitation of inpatients in cardiovascular medicine departments.

Methods: We report a case of coinfection with the 2019 novel coronavirus (SARS-CoV-2) and influenza A virus in a hospitalized patient with acute myocardial infarction. We used reverse transcription real-time fluorescence quantitative PCR to detect SARS-CoV-2 and influenza A virus and used the Ct value to represent the relative concentration of the above two viruses.

Results: The patient was tested for SARS-CoV-2 nucleic acid and influenza A and B virus nucleic acid in the early stage of hospitalization, and the results were negative. On the 39th day of admission, the nucleic acid test result for SARS-CoV-2 was positive (ORF1ab gene, Ct value 24.63; N gene, Ct value 24.55); on the 48th day of admission, the nucleic acid test result for influenza A virus was positive (Ct value, 21.32), indicating hospital-acquired respiratory virus coinfection.

Conclusions: Clinicians should be highly cognizant that SARS-CoV-2 may become a new high-incidence pathogen of nosocomial infection. In-hospital monitoring of common respiratory viruses should be considered to detect infected patients early and prevent common respiratory viruses from spreading in hospitals.