Computerized analysis of antimicrobial drugs interactions in biological systems using an IBM-PC microcomputer.

We have developed a computer program to analyse the individual and combined effects of two treatments applied concurrently to a biological system. Analysis is done in regard to: level of significance selected for the statistical test (two-sided Student's t test); number of data available; expected combined effect resulting from addition (computed by the program); experimental hypothesis tested (synergism or antagonism). The main program gives access to eight options: input of new data; input of data from file; addition or modification to data in memory; display on monitor the results from analysis or the contents of a data file; analysis with another level of significance; printout; kinetics of interaction; end of program. The program is designed to work with an IBM-PC, Epson MX/FX 80/100 printer and Roland DXY 800 plotter. Sample runs are given.