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Controlling the minimum gelation concentration (MGC) of low molecular weight (LMW) hydrogelators is a key for modulating gel properties, such as mechanical strength, viscoelasticity, and stability, which are crucial for applications ranging from drug delivery to tissue engineering. However, tweaking the MGC under specific conditions, such as pH and/or temperature, poses a considerable challenge. Herein, we varied the ionic strength of buffer solutions using NaCl for several LMW hydrogelators, including Fmoc-Phe, Fmoc-Tyr, Fmoc-Trp, Fmoc-Met, and Fmoc-Cha, and assessed their gelation efficiency at pH 7.

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Stress amplification and relaxation imaging around cracks in nanocomposite gels using ultrasound elastography.

Soft Matter

November 2024

Laboratoire de Sciences et Ingénierie de la Matière Molle, ESPCI Paris, Université PSL, Sorbonne Université, CNRS, F-75005 Paris, France.

The quantification and modeling of gel fracture under large strain and dissipative conditions is still an open issue. In this study, a novel method for investigating the mechanical behavior of gels under highly deformed states, specifically in the vicinity of the crack tip, was developed to gain insights into fracture processes. Shear wave elastography, originally developed for the biomedical community, is employed as a powerful tool to quantitatively map the local elasticity of model gels.

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Making Sticky-Slippery Switchable Fluorogels Through Self-Adaptive Bicontinuous Phase Separation.

Adv Mater

November 2024

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry and Chemical Engineering & Center for Advanced Low-dimension Materials, Donghua University, 2999 North Renmin Road, Shanghai, 201620, China.

Developing gel materials with tunable frictional properties is crucial for applications in soft robotics, anti-fouling, and joint protection. However, achieving reversible switching between extreme sticky and slippery states remains a formidable challenge due to the opposing requirements for energy dissipation on gel surfaces. Herein, a self-adaptive bicontinuous fluorogel is introduced that decouples lubrication and adhesion at varying temperatures.

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The development of bioadhesives that concurrently exhibit high adhesion strength, biocompatibility, and tunable properties and involve simple fabrication processes continues to be a significant challenge. In this study, a novel bioadhesive named DOTAGEL is synthesized by crosslinking gelatin (GA), dopamine (DA), and tannic acid (TA) in an unoxidized environment due to the advantage of controlling the degree of protonation in GA and TA, as well as controlling the degree of intermolecular amide and hydrogen bonding in the acidic medium. DOTAGEL (DA + TA + GA) shows superior adhesion strengths of 104.

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