Unlabelled: Current lung cancer screening (LCS) guidelines rely on age and smoking history. Despite its benefit, only 5%-15% of eligible patients receive LCS. Personalized screening strategies select individuals based on their lung cancer risk and may increase LCS's effectiveness. We assess current LCS practices and the acceptability of personalized LCS among primary care providers (PCP) in Texas. We surveyed 32,983 Texas-based PCPs on an existing network (Protocol 2019-1257; PI: Dr. Shete) and 300 attendees of the 2022 Texas Academy of Family Physicians (TAFP) conference. We analyzed the responses by subgroups of interest. Using nonparametric bootstrap, we derived an enriched dataset to develop logistic regression models to understand current LCS practices and acceptability of personalized LCS. Response rates were 0.3% (n = 91) and 15% (n = 60) for the 2019-1257 and TAFP surveys, respectively. Most (84%) respondents regularly assess LCS in their practice. Half of the respondents were interested in adopting personalized LCS. The majority (66%) of respondents expressed concerns regarding time availability with the personalized LCS. Most respondents would use biomarkers as an adjunct to assess eligibility (58%), or to help guide indeterminate clinical findings (63%). There is a need to enhance the engagement of Texas-based PCPs in LCS. Most of the respondents expressed interest in personalized LCS. Time availability was the main concern related to personalized LCS. Findings from this project highlight the need for better education of Texas-based PCPs on the benefits of LCS, and the development of efficient decision tools to ensure successful implementation of personalized LCS.
Prevention Relevance: Personalized LCS facilitated by a risk model and/or a biomarker test is proposed as an alternative to existing programs. Acceptability of personalized approach among PCPs is unknown. The goal of this study is to assess the acceptability of personalized LCS among PCPs.
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http://dx.doi.org/10.1158/1940-6207.CAPR-23-0359 | DOI Listing |
Sci Rep
December 2024
Animal Biotechnology Division, National Institute of Animal Science, Rural Development Administration, Wanju, Republic of Korea.
Small intestinal organoids are similar to actual small intestines in structure and function and can be used in various fields, such as nutrition, disease, and toxicity research. However, the basal-out type is difficult to homogenize because of the diversity of cell sizes and types, and the Matrigel-based culture conditions. Contrastingly, the apical-out form of small intestinal organoids is relatively uniform and easy to manipulate without Matrigel.
View Article and Find Full Text PDFArtif Intell Med
December 2024
Department of Electrical and Computer Engineering, Duke University, Durham, NC, United States of America; Medical Physics Graduate Program, Duke University, Durham, NC, United States of America; Department of Radiology, Duke University, Durham, NC, United States of America; Department of Biomedical Engineering, Duke University, Durham, NC, United States of America; Department of Radiation Oncology, Duke University, Durham, NC, United States of America; Department of Pathology, Duke University, Durham, NC, United States of America. Electronic address:
In this paper, we introduce a novel concordance-based predictive uncertainty (CPU)-Index, which integrates insights from subgroup analysis and personalized AI time-to-event models. Through its application in refining lung cancer screening (LCS) predictions generated by an individualized AI time-to-event model trained with fused data of low dose CT (LDCT) radiomics with patient demographics, we demonstrate its effectiveness, resulting in improved risk assessment compared to the Lung CT Screening Reporting & Data System (Lung-RADS). Subgroup-based Lung-RADS faces challenges in representing individual variations and relies on a limited set of predefined characteristics, resulting in variable predictions.
View Article and Find Full Text PDFBMC Womens Health
December 2024
IRCCS, Humanitas Research Hospital, Rozzano, MI, Italy.
Background: Severely abused nonpatient women report a high number of gastrointestinal (GI) symptoms and GI syndromes. Little is known about whether the abuse‒symptom relationship varies across different life, social, and community conditions.
Objective: To comparatively assess the timing, type and severity of physical and/or sexual abuse and GI symptoms of nonpatient women who contacted a lawyer for legal support with those who sought shelter in antiviolence centers.
J Environ Manage
December 2024
Division of Thermophysics Metrology, National Institute of Metrology, Beijing, 100029, China; Zhengzhou Institute of Metrology, Zhengzhou, 450001, China. Electronic address:
The increasing demand for air pollution control has driven the application of low-cost sensors (LCS) in air quality monitoring, enabling higher observation density and improved air quality predictions. However, the inherent limitations in data quality from LCS necessitate the development of effective methodologies to optimize their application. This study established a hybrid framework to enhance the accuracy of spatiotemporal predictions of PM, standard instrument measurements were employed as reference data for the remote calibration of LCS.
View Article and Find Full Text PDFEnviron Res
December 2024
Shenzhen Engineering Laboratory for Eco-efficient Recycled Materials, School of Environment and Energy, Peking University Shenzhen Graduate School, University Town, Xili, Nanshan District, Shenzhen, 518055, PR China. Electronic address:
Co-landfill of municipal solid waste (MSW) and bottom ash (BA) has accelerated the scaling of the leachate collection systems (LCS). The matrix of biofilm formation and mineral deposition makes the scaling process in LCS more complicated. However, the fate of metals released from BA and the role of microorganisms in the leachate, which determine the chemical and biological scaling, are not well understood; the scale adsorption ability is little discussed.
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