AI Article Synopsis
- The study focused on extracting and analyzing the chemical components of Qi-nan Aquilariae Lignum Resinatum using various chromatography techniques.
- Researchers successfully isolated and identified two new sesquiterpene compounds, aquqinanol C(1) and aquqinanol D(2), through advanced spectroscopic methods.
- The newly identified compounds showed protective effects against damage in PC12 cells induced by CORT in vitro, suggesting potential neuroprotective properties.
Article Abstract
This study aimed to investigate the chemical constituents of supercritical extract from Qi-nan Aquilariae Lignum Resinatum by silica gel column chromatography, thin-layer chromatography, and semi-preparative high-performance liquid chromatography. One new elemane-type and one new eudesmane-type sesquiterpene compounds were isolated from the extract, and their structures were identified by MS, UV, IR, NMR, and ECD spectroscopic techniques, and named aquqinanol C(1) and aquqinanol D(2). Both compounds are novel compounds. The neuroprotective effect of the compounds on CORT-induced PC12 cell damage was determined in vitro. The results showed that compounds 1 and 2 exhibited a certain protective effect against CORT-induced damage in PC12 cells.
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| http://dx.doi.org/10.19540/j.cnki.cjcmm.20230618.203 | DOI Listing |
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