AI Article Synopsis
- Marine sulfated polysaccharides (MSPs) are natural compounds found in marine organisms, known for their sulfate groups and diverse biological activities, including anticoagulation and tumor suppression.
- MSPs have structural similarities to heparan sulfate, which has led to extensive research on their potential use in treating diabetic nephropathy (DN), demonstrating effectiveness in both lab studies and live models.
- The paper reviews the anti-DN properties of MSPs, exploring their mechanisms and the relationship between their structure and biological activity, aiming to present MSPs as viable treatments for DN.
Article Abstract
Marine sulfated polysaccharide (MSP) is a natural high molecular polysaccharide containing sulfate groups, which widely exists in various marine organisms. The sources determine structural variabilities of MSPs which have high security and wide biological activities, such as anticoagulation, antitumor, antivirus, immune regulation, regulation of glucose and lipid metabolism, antioxidant, etc. Due to the structural similarities between MSP and endogenous heparan sulfate, a majority of studies have shown that MSP can be used to treat diabetic nephropathy (DN) in vivo and in vitro. In this paper, we reviewed the anti-DN activities, the dominant mechanisms and structure-activity relationship of MSPs in order to provide the overall scene of MSPs as a modality of treating DN.
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| http://dx.doi.org/10.1016/j.ijbiomac.2024.129269 | DOI Listing |
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