AI Article Synopsis
- - Four new diterpenoids (compounds 1-4) and four known diterpenoids (compounds 5-8) were extracted from the plant Euphorbia helioscopia L.
- - Compounds 1 and 2 are jathophanes with a complex 5/12 structure, while compound 3 is a rhamofolane with a 5/10 structure, and compound 4 is a unique euphorbia diterpene featuring a rare 5/10 fused ring system.
- - Anti-inflammatory tests showed that compound 4 significantly inhibited the NLRP3 inflammasome, achieving an IC value of 7.75 μM, confirmed by immunofluores
Article Abstract
Four new diterpenoids (1-4) and four known diterpenoids (5-8) were purified from the whole plant of Euphorbia helioscopia L. Compounds 1 and 2 were jathophanes diterpenoids with a 5/12 polycyclic systems, compound 3 was rhamofolane diterpenoid with a 5/10 bicyclic skeleton and compound 4 was a rare class of euphorbia diterpenes featuring an unusual 5/10 fused ring system. Anti-inflammatory activity tests were conducted on the separated compounds, indicating that compound 4 had significant inhibitory effect on NLRP3 inflammasome with an IC value of 7.75 μM. Further, the inhibitory effect of 4 was determined using immunofluorescence assays.
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| http://dx.doi.org/10.1016/j.fitote.2024.105821 | DOI Listing |
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