Urethral Bulking With Polyacrylamide Hydrogel Compared With Other Treatments for Stress Urinary Incontinence: A Cost-Effectiveness Analysis.

Obstet Gynecol

Division of Female Urology, Voiding Dysfunction and Pelvic Reconstructive Surgery, University of California, Irvine, Irvine, the Department of Obstetrics and Gynecology, Providence Saint John's Health Center, Santa Monica, and Urogynecology and Pelvic Reconstructive Surgery, Stanford University School of Medicine, Stanford, California; the Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, and Urogynecology and Reconstructive Pelvic Surgery, Yale University School of Medicine, New Haven, Connecticut; and the Division of Urogynecology and Pelvic Floor Disorders, Cleveland Clinic Women's Health Institute, Cleveland, Ohio.

Published: March 2024

AI Article Synopsis

  • - The study aimed to analyze the cost-effectiveness of polyacrylamide hydrogel urethral bulking compared to other treatments for stress urinary incontinence (SUI).
  • - Among the treatments evaluated, midurethral sling (MUS) showed the highest effectiveness followed closely by polyacrylamide hydrogel, with minimal differences in quality-adjusted life-years (QALYs).
  • - Polyacrylamide hydrogel becomes more cost-effective if over 58% of the procedures are done in-office, making it a reasonable option depending on patient preferences, even though MUS is the preferred treatment due to its higher effectiveness.

Article Abstract

Our objective was to perform a cost-effectiveness analysis comparing polyacrylamide hydrogel urethral bulking with other surgical and nonsurgical treatments for stress urinary incontinence (SUI). We created a cost-effectiveness analysis using TreeAge Pro, modeling eight SUI treatments. Treatment with midurethral sling (MUS) had the highest effectiveness (1.86 quality-adjusted life-years [QALYs]), followed by polyacrylamide hydrogel (1.82 QALYs), with a difference (Δ 0.02/year) less than the minimally important difference for utilities of 0.03 annually. When the proportion of polyacrylamide hydrogel urethral bulking procedures performed in the office setting is greater than 58%, polyacrylamide hydrogel is a cost-effective treatment for SUI, along with pessary, pelvic floor physical therapy, and MUS. Although MUS is more effective and, therefore, the preferred SUI treatment, polyacrylamide hydrogel is a reasonable alternative depending on patient preferences and treatment goals.

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Source
http://dx.doi.org/10.1097/AOG.0000000000005503DOI Listing

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