Organizers hope to save long-running project on canine aging and longevity.
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Pooled PPIseq: Screening the SARS-CoV-2 and human interface with a scalable multiplexed protein-protein interaction assay platform.
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SLAC National Accelerator Laboratory, Stanford University, Stanford, California, United States of America.
Protein-Protein Interactions (PPIs) are a key interface between virus and host, and these interactions are important to both viral reprogramming of the host and to host restriction of viral infection. In particular, viral-host PPI networks can be used to further our understanding of the molecular mechanisms of tissue specificity, host range, and virulence. At higher scales, viral-host PPI screening could also be used to screen for small-molecule antivirals that interfere with essential viral-host interactions, or to explore how the PPI networks between interacting viral and host genomes co-evolve.
View Article and Find Full Text PDFTargeting uPAR with an antibody-drug conjugate suppresses tumor growth and reshapes the immune landscape in pancreatic cancer models.
Sci Adv
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The Finsen Laboratory, Rigshospitalet, DK-2200 Copenhagen, Denmark.
Antibody-drug conjugates (ADCs) hold promise to advance targeted therapy of pancreatic ductal adenocarcinoma (PDAC), where the desmoplastic tumor stroma challenges effective treatment. Here, we explored the urokinase plasminogen activator receptor (uPAR) as a candidate ADC target in PDAC, harnessing its massive tumoral and stromal expression in this stroma-dense tumor. We generated a site-specific ADC offering high-affinity, cross-species reactivity, and efficient internalization of the anti-uPAR monoclonal antibody, FL1, carrying a potent anthracycline derivative (PNU-158692).
View Article and Find Full Text PDFIlluminating the dark mess of fibers: Application of circular cross polarized light in unravelling the bone tissue structure of the dermal pectoral girdle of Metoposaurus krasiejowensis.
J Anat
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Bonn Institute of Organismal Biology, Paleontology, University of Bonn, Bonn, Germany.
Current understanding of the histology of the dermoskeleton of tetrapods comes from fossilized and recent remains of skulls, osteoderms, carapace, plastron and other postcranial material which were always investigated using linear cross polarized light (LCPL) microscopy. The pectoral girdle of vast majority of non-amniote tetrapods, including temnospondyls evolved large ventrally located dermal bones- the interclavicle and a pair of clavicles. Despite that, there is a lack of information about the bone tissue structure from these postcranial dermal bones.
View Article and Find Full Text PDFCreating pragmatic, rapid-cycle, evidence-based innovation: The Kaiser Permanente Northern California Delivery Science and Applied Research (DARE) program.
Learn Health Syst
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Division of Research Kaiser Permanente Northern California Oakland California USA.
Introduction: Ongoing crises in the quality, affordability, sustainability, value, and equity of U.S. healthcare call for rapid, massive-scale innovations across multiple specialties.
View Article and Find Full Text PDFInvestigating the Role of Symptom Duration and Critical Shoulder Angle in Predicting Acromiohumeral Interval Reversibility in Patients With Massive Rotator Cuff Tears.
Orthop J Sports Med
January 2025
Department of Orthopaedics and Traumatology, Istanbul University Faculty of Medicine, Istanbul, Turkey.
Background: Acromiohumeral interval (AHI) reversibility is used to evaluate whether superior humeral migration is fixed or flexible in patients with massive rotator cuff tears (MRCTs). AHI reversibility is measured as the difference in the AHI observed between standard and stress radiography. However, factors affecting AHI reversibility have not been studied in the existing literature.
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