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Rare, Tightly-Bound, Multi-Cellular Clusters in the Pancreatic Ducts of Adult Mice Function Like Progenitor Cells and Survive and Proliferate After Acinar Cell Injury. | LitMetric

AI Article Synopsis

  • Researchers have discovered a rare population of pancreatic ductal progenitor-like cells in adult mice, making up about 0.1% of total pancreatic cells and identifiable by specific surface markers.
  • These cells show remarkable abilities for self-renewal and can differentiate into various cell types, suggesting a role in tissue maintenance and repair after injury.
  • Their resistance to digestion and ability to proliferate after pancreatic injury highlights their potential significance in understanding diabetes treatment and cancer development.

Article Abstract

Pancreatic ductal progenitor cells have been proposed to contribute to adult tissue maintenance and regeneration after injury, but the identity of such ductal cells remains elusive. Here, from adult mice, we identify a near homogenous population of ductal progenitor-like clusters, with an average of 8 cells per cluster. They are a rare subpopulation, about 0.1% of the total pancreatic cells, and can be sorted using a fluorescence-activated cell sorter with the CD133highCD71lowFSCmid-high phenotype. They exhibit properties in self-renewal and tri-lineage differentiation (including endocrine-like cells) in a unique 3-dimensional colony assay system. An in vitro lineage tracing experiment, using a novel HprtDsRed/+ mouse model, demonstrates that a single cell from a cluster clonally gives rise to a colony. Droplet RNAseq analysis demonstrates that these ductal clusters express embryonic multipotent progenitor cell markers Sox9, Pdx1, and Nkx6-1, and genes involved in actin cytoskeleton regulation, inflammation responses, organ development, and cancer. Surprisingly, these ductal clusters resist prolonged trypsin digestion in vitro, preferentially survive in vivo after a severe acinar cell injury and become proliferative within 14 days post-injury. Thus, the ductal clusters are the fundamental units of progenitor-like cells in the adult murine pancreas with implications in diabetes treatment and tumorigenicity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016848PMC
http://dx.doi.org/10.1093/stmcls/sxae005DOI Listing

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