AI Article Synopsis
- Cyclic GMP-AMP (cGAMP) is a secondary messenger produced by cGAMP synthase (cGAS), playing a key role in regulating processes like cell growth, death, immune responses, and inflammation.
- cGAS gets activated when it detects foreign DNA in the cytoplasm, leading to significant inflammatory reactions through the cGAS-STING signaling pathway.
- The review examines the potential of targeting cGAS and cGAMP in developing inhibitors as chemopreventive therapies, while also exploring cGAS's function in recognizing self versus foreign DNA and its activities in the nucleus.
Article Abstract
Cyclic GMP-AMP (cGAMP), synthesized by cGAMP synthase (cGAS), serves as a secondary messenger that modulates various cellular processes, including cell proliferation, cell death, immune response, and inflammation. cGAS is activated upon detecting cytoplasmic DNA, which may originate from damaged genomic and mitochondrial DNA or from viral and bacterial infections. The presence of DNA in the cytoplasm can trigger a substantial inflammatory reaction and cytokine production via the cGAS-STING signaling pathway. Consequently, specific inhibitors targeting this pathway hold significant potential as chemopreventive agents. In this review, we explore the potential effectiveness of modulating cGAS activity. We discuss the role of cGAMP, the mechanism of action for distinguishing between self and foreign DNA, and the possible functions of cGAS within the nucleus.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10774482 | PMC |
| http://dx.doi.org/10.15430/JCP.2023.28.4.143 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!