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Bibliometric analysis of nanotechnology in spinal cord injury: current status and emerging frontiers.
Front Pharmacol
December 2024
Department of Orthopedics, Ningbo No. 6 Hospital, Ningbo, Zhejiang, China.
Objective: The objective of this study was to analyze the impact of nanotechnology on the treatment and recovery of spinal cord injury (SCI), a condition that has profound global effects on physical and psychological health.
Methods: We utilized the Web of Science Core Collection to obtain bibliometric data. With the tools such as VOSviewer and CiteSpace, we conducted a comprehensive review of 422 relevant publications to identify research trends and influential works in the field of nanotechnology applied to SCI.
Berberine Derivative B68 Promotes Tumor Immune Clearance by Dual-Targeting BMI1 for Senescence Induction and CSN5 for PD-L1 Degradation.
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Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Promoting tumor cell senescence arrests the cell cycle of tumor cells and activates the immune system to eliminate these senescent cells, thereby suppressing tumor growth. Nevertheless, PD-L1 positive senescent tumor cells resist immune clearance and possess the ability to secret various cytokines and inflammatory factors that stimulate the growth of tumor cells. Consequently, drugs capable of both triggering senescence in tumor cells and concurrently diminishing the expression of PD-L1 to counteract immune evasion are urgently needed.
View Article and Find Full Text PDFCrosstalk between periodontitis and cardiovascular risk.
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Institute for Molecular Cardiovascular Research (IMCAR), Uniklinik RWTH Aachen, RWTH Aachen University, Aachen, Germany.
Recent demographic developments resulted in an aged society with a rising disease burden of systemic and non-communicable diseases (NCDs). In cardiovascular disease (CVD), a NCD with high morbidity and mortality, recent preventive strategies include the investigation of comorbidities to reduce its significant economic burden. Periodontal disease, an oral bacterial-induced inflammatory disease of tooth-supporting tissue, is regulated in its prevalence and severity by the individual host response to a dysbiotic oral microbiota.
View Article and Find Full Text PDFChemogenetic activation of astrocytes modulates sleep-wakefulness states in a brain region-dependent manner.
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Department of Biological Sciences, Faculty of Science, Hokkaido University, Sapporo, Japan.
Study Objectives: Astrocytes change their intracellular calcium (Ca) concentration during sleep/wakefulness states in mice. Furthermore, the Ca dynamics in astrocytes vary depending on the brain region. However, it remains unclear whether alterations in astrocyte activity can affect sleep-wake states and cortical oscillations in a brain region-dependent manner.
View Article and Find Full Text PDFTailoring a Transition Metal Dual-Atom Catalyst via a Screening Descriptor in Li-S Batteries.
ACS Nano
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College of Energy, Soochow Institute for Energy and Materials Innovations, Jiangsu Provincial Key Laboratory for Advanced Carbon Materials and Wearable Energy Technologies, Soochow University, Suzhou 215006, China.
The adsorption-conversion paradigm of polysulfides during the sulfur reduction reaction (SRR) is appealing to tackle the shuttle effect in Li-S batteries, especially based upon atomically dispersed electrocatalysts. However, mechanistic insights into such catalytic systems remain ambiguous, limiting the understanding of sulfur electrochemistry and retarding the rational design of available catalysts. Herein, we systematically explore the polysulfide adsorption-conversion essence via a geminal-atom model system to understand the catalyst roles toward an expedited SRR.
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