Serge Charpak (Institut de la Vision) discusses his pioneering work in imaging of sensory processing and neurovascular coupling, in an interview with former trainee and fellow Neurophotonics Editorial Board Member Jérôme Lecoq (Allen Institute).
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10778265 | PMC |
http://dx.doi.org/10.1117/1.NPh.11.1.010401 | DOI Listing |
J Neurol Sci
November 2024
Inserm, Neuro-Diderot, U1141 and Université Paris-Cité, F-75019 Paris, France; Translational Neurovascular Centre and Centre de reference CERVCO, FHU NeuroVasc, Paris, France. Electronic address:
fMRI-based studies on neurodegenerative diseases rarely report single-subject information, which is useful for assessing potential biomarkers. In a previous fMRI study, CADASIL patients showed, at the group level, a significant reduction of the long-lasting visually stimulated hyperaemic response. Here, we used data interpolation and computed a hemodynamic response function from the 20-s visual response to achieve a 40-s response prediction at the individual level.
View Article and Find Full Text PDFNat Commun
September 2024
Sorbonne Université, Inserm U968, Vision Institute, Paris, France.
Neurovascular coupling (NVC), which mediates rapid increases in cerebral blood flow in response to neuronal activation, is commonly used to map brain activation or dysfunction. Here we tested the reemerging hypothesis that CO generated by neuronal metabolism contributes to NVC. We combined functional ultrasound and two-photon imaging in the mouse barrel cortex to specifically examine the onsets of local changes in vessel diameter, blood flow dynamics, vascular/perivascular/intracellular pH, and intracellular calcium signals along the vascular arbor in response to a short and strong CO challenge (10 s, 20%) and whisker stimulation.
View Article and Find Full Text PDFNeurophotonics
July 2022
Sorbonne Université, Inserm, CNRS, Institut de la Vision, Paris, France.
Significance: All functional brain imaging methods have technical drawbacks and specific spatial and temporal resolution limitations. Unraveling brain function requires bridging the data acquired with cellular and mesoscopic functional imaging. This imposes the access to animal preparations, allowing longitudinal and multiscale investigations of brain function in anesthetized and awake animals.
View Article and Find Full Text PDFPflugers Arch
January 2023
Center for Neural Engineering, Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802, USA.
Oxygen is critical for neural metabolism, but under most physiological conditions, oxygen levels in the brain are far more than are required. Oxygen levels can be dynamically increased by increases in respiration rate that are tied to the arousal state of the brain and cognition, and not necessarily linked to exertion by the body. Why these changes in respiration occur when oxygen is already adequate has been a long-standing puzzle.
View Article and Find Full Text PDFNeuron
May 2022
Institut de la Vision, Sorbonne Université, INSERM, CNRS, 75012 Paris, France. Electronic address:
Functional ultrasound (fUS) is an emerging technique that measures blood flow to report brain activity. In this issue of Neuron, Nunez-Elizalde et al. (2022) use simultaneous electrophysiological and fUS measurements to quantify the relationship between firing and fUS signals in awake mice.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!