AI Article Synopsis
- Fengycin shows promise for biological control due to its safety and ability to break down in the environment.
- Researchers engineered strains to boost the production of key amino acid precursors, enhancing fengycin biosynthesis significantly.
- In bioreactor tests, the microbial consortium produced fengycin at high levels (3290 mg·L), demonstrating its effective antifungal properties, which could be utilized as a food preservative.
Article Abstract
Fengycin has great potential for applications in biological control because of its biosafety and degradability. In this study, the addition of exogenous precursors increased fengycin production by . was engineered to produce high levels of precursors (Thr, Pro, Val, and Ile) to promote the biosynthesis of fengycin. Furthermore, recombinant . and providing amino acid and fatty acid precursors were co-cultured to improve fengycin production by in a three-strain artificial consortium, in which fengycin production was 2100 mg·L. In addition, fengycin production by the consortium in a 5 L bioreactor reached 3290 mg·L. Fengycin had a significant antifungal effect on , which illustrates its potential as a food preservative. Taken together, this work provides a new strategy for improving fengycin production by a microbial consortium and metabolic engineering.
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| http://dx.doi.org/10.1021/acs.jnatprod.3c00705 | DOI Listing |
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