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High-level production of free fatty acids from lignocellulose hydrolysate by co-utilizing glucose and xylose in yeast.
Synth Syst Biotechnol
June 2025
Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, PR China.
Lignocellulose bio-refinery via microbial cell factories for chemical production represents a renewable and sustainable route in response to resource starvation and environmental concerns. However, the challenges associated with the co-utilization of xylose and glucose often hinders the efficiency of lignocellulose bioconversion. Here, we engineered yeast to effectively produce free fatty acids from lignocellulose.
View Article and Find Full Text PDFTransketolase promotes osteosarcoma progression through the YY1-PAK4 axis.
FEBS J
January 2025
Department of Orthopedics, Wuhan Hospital of Traditional Chinese and Western Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Osteosarcoma, a malignant bone tumor that occurs in adolescents, proliferates and is prone to pulmonary metastasis. Osteosarcoma is characterized by high genotypic heterogeneity, making it difficult to identify reliable anti-osteosarcoma targets. The genotype of osteosarcoma may be highly dynamic, but its high dependence on energy remains constant.
View Article and Find Full Text PDFBuffered Hydroxyl Radical for Photocatalytic Non-Oxidative Methane Coupling.
Angew Chem Int Ed Engl
January 2025
State Key Laboratory of Catalysis and Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
Hydroxy radical (⋅OH) is a prestigious oxidant that allows the cleavage of strong chemical bonds of methane but is untamed, leading to over-oxidation of methane and waste of oxidants, especially at high methane conversion. Here, we managed to buffer ⋅OH in an aqueous solution of photo-irradiated Fe, where ⋅OH almost participates in methane oxidation. Due to the interaction between Fe and SO , the electron transfer from OH to excited-state Fe for ⋅OH generation is retarded, while excessive ⋅OH is consumed by generated Fe to restore Fe.
View Article and Find Full Text PDFThe pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes.
Nat Metab
January 2025
Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
Bone lengthening and fracture repair depend on the anabolic properties of chondrocytes that function in an avascular milieu. The limited supply of oxygen and nutrients calls into question how biosynthesis and redox homeostasis are guaranteed. Here we show that glucose metabolism by the pentose phosphate pathway (PPP) is essential for endochondral ossification.
View Article and Find Full Text PDFAdvance Glycation End Products Inhibition by Peel Extract; Characterization, LCMS-QTOF Analysis, and Biological Evaluation.
Food Sci Nutr
December 2024
NPRL, Department of Pharmacognosy, Faculty of Pharmacy Gomal University Dera Ismail Khan Khyber Pakhtunkhwa Pakistan.
Advance glycation end products (AGEs) are the main reason for diabetic complications. Persistent hyperglycemia and non-enzymatic glycation increase the rate of AGEs formation. Natural functional food-based approaches are mainly under investigation these days to discover new treatment options.
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