AI Article Synopsis
- Progressive cognitive decline in Alzheimer's disease (AD) poses significant challenges, with current treatments offering only short-term relief through acetylcholinesterase inhibition.
- Promising new approaches include butyrylcholinesterase inhibitors, multi-target ligands, and compounds targeting oxidative stress and inflammation, with cinnamate derivatives showing enhanced efficacy when combined with standard AD treatments.
- Cinnamic acid stands out as a versatile structure with potential as an AD therapeutic, especially compounds with specific methoxy substitutions that improve effectiveness and suggest the need for further exploration of molecular size effects.
Article Abstract
Progressive cognitive decline in Alzheimer's disease (AD) is a growing challenge. Present therapies are based on acetylcholinesterase inhibition providing only temporary relief. Promising alternatives include butyrylcholinesterase (BuChE) inhibitors, multi-target ligands (MTDLs) that address the multi-factorial nature of AD, and compounds that target oxidative stress and inflammation. Cinnamate derivatives, known for their neuroprotective properties, show potential when combined with established AD agents, demonstrating improved efficacy. They are being positioned as potential AD therapeutic leads due to their ability to inhibit Aβ accumulation and provide neuroprotection. This article highlights the remarkable potential of cinnamic acid as a basic structure that is easily adaptable and combinable to different active groups in the struggle against Alzheimer's disease. Compounds with a methoxy substitution at the para-position of cinnamic acid display increased efficacy, whereas electron-withdrawing groups are generally more effective. The effect of the molecular volume is worthy of further investigation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10778916 | PMC |
| http://dx.doi.org/10.3390/ijms25010582 | DOI Listing |
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