AI Article Synopsis
- Glycemic control and maintaining pancreatic β-cell function are key challenges in treating type 2 diabetes (T2DM), leading to ongoing research in this area.
- Glucokinase activators (GKAs) are a new class of drugs aimed at improving blood sugar regulation and β-cell performance, with recent developments showing promise in overcoming past limitations.
- Dorzagliatin and TTP399, two newer GKAs, have shown positive results in clinical trials, highlighting their potential effectiveness and safety in managing T2DM.
Article Abstract
Achieving glycemic control and sustaining functional pancreatic β-cell activity remains an unmet medical need in the treatment of type 2 diabetes mellitus (T2DM). Glucokinase activators (GKAs) constitute a class of anti-diabetic drugs designed to regulate blood sugar levels and enhance β-cell function in patients with diabetes. A significant progression in GKA development is underway to address the limitations of earlier generations. Dorzagliatin, a dual-acting GKA, targets both the liver and pancreas and has successfully completed two phase III trials, demonstrating favorable results in diabetes treatment. The hepato-selective GKA, TTP399, emerges as a strong contender, displaying clinically noteworthy outcomes with minimal adverse effects. This paper seeks to review the current literature, delve into the mechanisms of action of these new-generation GKAs, and assess their efficacy and safety in treating T2DM based on published preclinical studies and recent clinical trials.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10779250 | PMC |
| http://dx.doi.org/10.3390/ijms25010571 | DOI Listing |
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