AI Article Synopsis
- Head and neck cancer (HNC) is a common type of cancer with survival rates between 30% to 70%, heavily influenced by tumor stage and location.
- Metastasis significantly affects survival, especially in head and neck squamous cell carcinoma (HNSCC) patients, who often have a prognosis of less than a year if the disease is metastatic.
- The review highlights the need for more research on the role of matrix metalloproteinases (MMPs) and their inhibitors in HNC, particularly regarding their impact on tumor behavior and response to radiotherapy.
Article Abstract
Head and neck cancer (HNC) is among the ten most frequent tumours, with 5-year survival rates varying from 30% to 70% depending on the stage and location of the tumour. HNC is traditionally known as head and neck squamous cell carcinoma (HNSCC), since 90% arises from epithelial cells. Metastasis remains a major cause of mortality in patients with HNSCC. HNSCC patients with metastatic disease have an extremely poor prognosis with a survival rate of less than a year. Matrix metalloproteinases (MMPs) have been described as biomarkers that promote cell migration and invasion. Radiotherapy is widely used to treat HNSCC, being a determining factor in the alteration of the tumour's biology and microenvironment. This review focuses on analysing the current state of the scientific literature on this topic. Although few studies have focused on the role of these proteinases in HNC, some authors have concluded that radiotherapy alters the behaviour of MMPs and tissue inhibitors of metalloproteinases (TIMPs). Therefore, more research is needed to understand the roles played by MMPs and their inhibitors (TIMPs) as prognostic biomarkers in patients with HNC and their involvement in the response to radiotherapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10778974 | PMC |
| http://dx.doi.org/10.3390/ijms25010527 | DOI Listing |
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