AI Article Synopsis
- Sepsis from peritonitis triggers an inflammatory response, and mesenchymal stromal cells (MSCs) might help modulate the immune system as a new treatment option.
- In a mouse study, researchers compared the effects of human adipose mesenchymal stem cells (hASCs) and modified hASCs (enhanced for better inflammation targeting) to see their impact on inflammation during peritonitis.
- Ultimately, the study found that both standard and genetically modified hASCs were safe and effective treatments, showing no significant differences in anti-inflammatory effects between the two groups when administered directly into the peritoneum.
Article Abstract
Sepsis due to peritonitis is a process associated with an inflammatory state. Mesenchymal stromal cells (MSCs) modulate the immune system due to the paracrine factors released and may be a therapeutic alternative. Three treatment groups were developed in a murine model of peritonitis to verify the effect of human adipose mesenchymal stem cell (hASCs). Additionally, a temporary modification was carried out on them to improve their arrival in inflamed tissues (CXCR4), as well as their anti-inflammatory activity (IL-10). The capacity to reduce systemic inflammation was studied using a local application (peritoneal injection) as a treatment route. Comparisons involving the therapeutic effect of wild-type ASCs and ASCs transiently expressing CXCR4 and IL-10 were carried out with the aim of generating an improved anti-inflammatory response for sepsis in addition to standard antibiotic treatment. However, under the experimental conditions used in these studies, no differences were found between both groups with ASCs. The peritoneal administration of hASCs or genetically modified hASCs constitutes an efficient and safe therapy in our model of mouse peritonitis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10778615 | PMC |
| http://dx.doi.org/10.3390/ijms25010520 | DOI Listing |
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