AI Article Synopsis
- SIRT6 is an NAD-dependent deacetylase mainly found in the nucleus, playing critical roles in histone modification, DNA repair, cell cycle regulation, and apoptosis.
- Disruptions in SIRT6 levels are linked to the emergence and progression of various cancers, highlighting the need to understand its biological functions in detail.
- The review discusses the implications of SIRT6 in cancer development and explores the potential of small molecule modulators to act as anti-cancer therapeutics.
Article Abstract
SIRT6 is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, predominantly located in the nucleus, that is involved in the processes of histone modification, DNA repair, cell cycle regulation, and apoptosis. Disturbances in SIRT6 expression levels have been observed in the development and progression of various types of cancer. Therefore, it is important to better understand the role of SIRT6 in biochemical pathways and assign it specific biological functions. This review aims to summarize the role of SIRT6 in carcinogenesis and tumor development. A better understanding of the factors influencing SIRT6 expression and its biological role in carcinogenesis may help to develop novel anti-cancer therapeutic strategies. Moreover, we discuss the anti-cancer effects and mechanism of action of small molecule SIRT6 modulators (both activators and inhibitors) in different types of cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10779230 | PMC |
| http://dx.doi.org/10.3390/ijms25010497 | DOI Listing |
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