AI Article Synopsis

  • * Recent research highlights that cell-free miRNAs from blood samples can be a non-invasive way to analyze endometrial receptivity, potentially replacing traditional methods.
  • * In this study, 111 blood samples were examined using advanced sequencing, achieving a high accuracy of 95.9% in predicting endometrial receptivity status, with significant differences in miRNA expression noted between various receptivity stages.

Article Abstract

MicroRNAs (miRNAs) can regulate the expression of genes involved in the establishment of the window of implantation (WOI) in the endometrium. Recent studies indicated that cell-free miRNAs in uterine fluid and blood samples could act as alternative and non-invasive sample types for endometrial receptivity analysis. In this study, we attempt to systematically evaluate whether the expression levels of cell-free microRNAs in blood samples could be used as non-invasive biomarkers for assessing endometrial receptivity status. We profiled the miRNA expression levels of 111 blood samples using next-generation sequencing to establish a predictive model for the assessment of endometrial receptivity status. This model was validated with an independent dataset ( = 73). The overall accuracy is 95.9%. Specifically, we achieved accuracies of 95.9%, 95.9%, and 100.0% for the pre-receptive group, the receptive group, and the post-respective group, respectively. Additionally, we identified a set of differentially expressed miRNAs between different endometrial receptivity statuses using the following criteria: -value < 0.05 and fold change greater than 1.5 or less than -1.5. In conclusion, the expression levels of cell-free miRNAs in blood samples can be utilized in a non-invasive manner to distinguish different endometrial receptivity statuses.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10779357PMC
http://dx.doi.org/10.3390/ijms25010076DOI Listing

Publication Analysis

Top Keywords

endometrial receptivity
20
blood samples
16
expression levels
12
predictive model
8
cell-free mirnas
8
levels cell-free
8
receptivity status
8
receptivity statuses
8
expression
5
endometrial
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!